The interpretation of cytogenetic abnormalities in multiple myeloma (MM) is often a challenging task. MM is characterized by several cytogenetic abnormalities that occur at various time points in the disease course. The interpretation of cytogenetic results in MM is complicated by the number and complexity of the abnormalities, the methods used to detect them and the disease stage at which they...

introduction: most of the hematologic malignancies are heterogenous with regard to morphology, immunophenotype, and genetic rearrangements. multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in these patients. patients and methods: bone marrow sam...

BACKGROUND The accurate identification of cytogenetic abnormalities in multiple myeloma (MM) has become more important over recent years for the development of new diagnostic and prognostic markers. In this study, we retrospectively analyzed the cytogenetic aberrations in MM cases as an initial assessment in a single institute. METHODS We reviewed the cytogenetic results from 222 patients who...

Uterine leiomyomata (myomas) are associated with a variety of characteristic cytogenetic abnormalities. The significance of these chromosomal aberrations in the pathobiology of myomas remains to be determined. The present study investigated the relationship between myoma cytogenetic abnormalities and size. A total of 114 myoma specimens were obtained from 92 patients undergoing myomectomy or hy...

Chronic kidney disease (CKD) is much more common than people recognize, and habitually goes undetected and undiagnosed until the disease is well advanced or when their kidney functions is down to 25% of normal function. Genetic and non-genetic factors contribute to cause CKD. Non-genetic factors include hypertension, High level of DNA damage due to the production of reactive oxygen species and ...

AIM The aim of prenatal diagnostics is to provide information of the genetic abnormalities of the fetus early enough for the termination of pregnancy to be possible. Chromosomal abnormalities can be detected in an unborn child through the use of cytogenetic, molecular- cytogenetic and molecular methods. In between them, central spot is still occupied by cytogenetic methods. In cases where use o...

background: in algeria, the data on infertility and its various causes are rare. recently, the introduction of assisted reproduction has allowed expecting that 300000 couples, which represent 7% of couples of reproductive age, face difficulty conceiving a child. knowing that most idiopathic cases are likely to be due to chromosomal abnormalities, we aimed to investigate genetic defects by karyo...

tea (camellia sinensis) is one of the most economically important crops and is considered tobe the national drink of iran. although there has been an intensive cytogenetic study of tea in differentregions of the world, there has been no report from iran. therefore, the present investigation was carriedout in order to present the basic cytogenetical features of various tea cultivators grown in t...

Aim. The main goal of this study was to the anti-radiation effect guaninium-zinc chloride complex on cytogenetic changes in irradiated rats. Methods. White rats Wistar line with an average weight 110-125 grams served as material for detection complex. Animals were injected intraperitoneally solutions at a concentration 40 mg/kg 2 hours before irradiation and subjected general uniform gamma from...

Adenosine triphosphate-binding cassette B1 (MDR1multiple drug resistance gene1), a drug transporter gene encodes a transmembrane glycoprotein (P-gp), which functions as an efflux pump for various structurally unrelated anticancer agents and toxins. Our main objective is to study MDR1 gene polymorphism at C3435T in chronic myeloid leukemia (CML) to understand its association with development and...