Linear, dimeric, tetrameric, and cyclic peptides derived from lactoferricin B, containing the RRWQWR motif, were designed, synthesized, purified, and characterized using RP-HPLC chromatography and MALDI-TOF mass spectrometry. The antibacterial activity of the designed peptides against E. coli (ATCC 11775 and 25922) and their cytotoxic effect against MDA-MB-468 and MDA-MB-231 breast cancer cell ...

Scorpion venom toxicity is one of the major medical concerns from old years, due to its influence on human activities and health. From many years ago a lot of researches established to examine different aspects of venom toxicity and its effects on different organs. During these years researchers are doing more specific studies on the cytotoxicity of scorpion venom. In Iran, Odonthobuthus doriae...

Background and objectives: Cancer is the third leading cause of mortality and morbidity in Iran and kills out about 30000 people a year. The drugs used to treat cancer have many side effects. So developing novel and effective drugs with lower side effects has a great importance. Located in the north-west of Iran, Ardebil province has a rich plant diversity which the biological ...

Scorpion venom toxicity is one of the major medical concerns from old years, due to its influence on human activities and health. From many years ago a lot of researches established to examine different aspects of venom toxicity and its effects on different organs. During these years researchers are doing more specific studies on the cytotoxicity of scorpion venom. In Iran, Odonthobuthus doriae...

OBJECTIVE To evaluate the impact of Photolon on cytostatic and cytotoxic effects of therapeutic range ultrasound in C6 glioma cells. METHODS C6 glioma cells in suspension or monolayer cell culture were exposed to ultrasound (880 kHz, 0.2-0.7 W/cm2) in the presence or absence of Photolon at the concentration of 1 μg/ml in the culture medium, and then cell viability was evaluated. RESULTS Pho...

angiogenesis, formation of new blood vessels, play an important role in some diseases such as cancer and its metastasis. using angiogenesis inhibitors, therefore, is one of the ways for cancer treatment and prevention of metastasis. medicinal plants have been shown to play a major role in the treatment of a variety of cancers. in this direction, cytotoxic and angiogenic effects of oleo gum resi...

BACKGROUND Rotavirus (RV) induces diarrhoea through a sequence of enterotoxic and cytotoxic effects. The former are NSP4-dependent, induce calcium-dependent chloride secretion and involve oxidative stress. Diosmectite (DS) is a natural clay that has been recommended as an active therapy for diarrhoea, but the mechanism of its effect is not clear. Electrical parameters may be used to measure the...

perforin gene (prf1) mutations have been reported in 20-30% of patients with familial hemophagocytic lymphohistiocytosis (fhl), an immune disorder of infancy and early childhood. cytotoxic t and natural killer (nk) cell activities are remarkably reduced or ab-sent in fhl patients. we report the first cases of familial hemophagocytic lymphohistiocy-tosis in an iranian family with two siblings. e...

few studies have been conducted on the causative factors associated with the development of cancer. infection by high risk human papillomaviruses (hpvs) have been implicated as causative agents in a variety of cancers. hpv is capable of evading immune system and establishing persistent infections. prolonged infection and lesion maintenance are associated with higher risk of neoplastic progressi...

the medicinal plants have been used since ancient times and are still utilized by the majority of the population. hence, it is essential to investigate the cytotoxic and genotoxic effects of these plants. the aim of this study was to evaluate the toxic effects of fennel seeds decoctions, traditionally used in iran as an herbal remedy.  the cytotoxicity was tested in vitro using allium cepa l. r...