objective(s): chalcones and their rigid analogues represent an important class of small molecules having anticancer activities. therefore, in this study the synthesis and cytotoxic activity of new 3-benzylidenchroman-4-ones were described as rigid chalcone analogues.   materials and methods: the reaction of resorcinol with 3-chloropropionic acid in the presence of cf3so3h was afforded correspon...

purpose : cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of behçet’s disease (bd). the purpose of this study was to evaluate the outcome of eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. methods : chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. prednisolone was concomita...

the genus stachys belongs to lamiaceae family with about 300 species and worldwide distribution. in the present study, the cytotoxic activity of four fractions of different satchys species (s. byzatina c. koch., s. inflata benth., s. setifera ten. and s. persica gmel.), has been investigated against ht-29 (colon carcinoma), caco-2 (colorectal adenocarcinoma), t-47d (breast ductal carcinoma) and...

Purpose: To determine the cytotoxic and antiviral potentials of Euphorbia milii var. splendens leaf against Peste des petits ruminants virus (PPRV).
 Methods: The methanol extract, as well n- hexane, chloroform, ethyl acetate, butanol fractions E. leaves were screened for activities PPRV using Vero cell line 3-(4,5-dimethylthiazol-2-yl)-2,diphenyltetrazolium bromide (MTT) assay.
 Resu...

The present study was designed to investigate the anti-melanogenic and cytotoxic activities of methanol extract of Phlomis kurdica. The antioxidant and anti-tyrosinase activity of MeOH extract from P. kurdica (MPk) were examined by DPPH radical scavenging and mushroom tyrosinase activity assays (in vitro), respectively. Furthermore, the effect of MPk on the melanin content, cellular tyrosinase ...