For successful implantation, biomaterials need excellent corrosion and wear resistance in the body environment, a combination of high strength low modulus, appropriate ductility non-cytotoxic. Due to their unique mechanical properties durability, metallic have been widely utilised clinical applications, such as joint replacements, dental root implants, orthopaedic fixation devices, cardiovascul...

This study investigated the cytotoxic effect of uvangoletin on HL-60 cells, and the effects of uvangoletin on myelosuppression, leucopenia, gastrointestinal tract disturbances and the possible cytotoxic mechanisms by using CCK-8, flow cytometry, western blot, xenograft, cyclophosphamide-induced leucopenia, copper sulfate-induced emesis and ethanol-induced gastric mucosal lesions assays. The res...

a series of 2-amino-4-(nitroalkyl)-4h-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using dbu (1,8-diazabicyclo[5.4.0]undec-7-ene) as a catalyst at room temperature. mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. the cytotoxic activity of target compounds were evaluated against t...

objective(s) as an important class of natural products, coumarins exhibit many biological activities and the diversity of their bioactivity is so huge that the pharmacological promiscuity has been applied on their case. oxypeucedanine also named as prangolarin is a linear furanocoumarin with an oxygenated prenylated substitution at c-5 of the nucleus. to our knowledge, there are few reports on ...

The leukocyte integrin LFA-1 (CD11a/CD18) plays an important role in lymphocyte recirculation and homotypic interactions. Leukocytes from mice lacking CD11a displayed defects in in vitro homotypic aggregation, in proliferation in mixed lymphocyte reactions, and in response to mitogen. Mutant mice mounted normal cytotoxic T cell (CTL) responses against systemic LCMV and VSV infections and showed...

A major 18-kD IgE-binding protein from Aspergillusfumigates (AspfI) has been purified . Partial amino acid sequencing of Asp f I showed extensive sequence homology (95%) between Asp fI and a cytotoxin (mitogillin) produced byA. restrictus. Crossinhibition radioimmunoassay using murine monoclonal antibody and human IgG and IgE antibodies showed that AspfI and mito were antigenically indistinguis...

We studied cytogenetic reactions of Scots pine seedlings to heavy metals - lead, cupric and zinc nitrates applied at concentrations 0.5 to 2000 µM. We determined the range of concentrations of heavy metals that causes mutagenic effect. Lead was found to cause the strongest genotoxicity as manifested by significant increase in the frequency of pathological mitosis, occurrence of fragmentations a...

There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress-induced injuries that may contribute to disease progression. Pathogen invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) in infectious etiologies. However, our understanding of the source and role ...

the present study was carried out to investigate cytotoxic activity of flower, leaf, stem and root extracts of five artemisia species against breast cancer cell line (mcf7) and human embryonic kidney normal cell line (hek293). the studied artemisia species were a. absinthium , a. vulgaris , a. incana , a. fragrans and a. spicigera . the cytotoxic activity was measured by mtt assay at different ...

Using limiting dilutions of responding cells in mouse mixed leukocyte cultures, we obtained direct estimates of the minimum frequency of precursors of cytotoxic T lymphocytes (CTL.P) for a variety of antigens. Depending on the strain combination, there were as many as 4-15 CTL.P reactive to DBA/2 among 10(4) lymph node cells. Taking into account that only 5-10% of peripheral T lymphocytes have ...