نتایج جستجو برای: cytotoxicity tests

تعداد نتایج: 380773  

Journal: :iranian journal of pharmaceutical research 0
xinran bao dalian medical university han liao dalian medical university jiao qu dalian medical university yong sun dalian medical university xin guo dalian medical university enxia wang dalian medical university

quercetin, a ubiquitous flavonol, represents a promising leading drug for development of new chemotherapeutic agents. however, its limited cytotoxicity to cancer cells hampers its clinical use. in order to obtain novel quercetin derivatives with superior cytotoxicity, seven alkylated quercetin derivatives were synthesized. solubility of these derivatives was determined by turbidimetry. cytotoxi...

Journal: :razavi international journal of medicine 0
saeed abtahi department pediatrics cardiology, mashhad branch, islamic azad university, mashhad, ir iran javad behravan department of biotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran melika ehtesham gharaee department of biotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, ir iran; department of biostatistics, mashhad branch, islamic azad university, mashhad, ir iran malihe aghasizadeh sharbaf innovative medical research center, department of biochemistry, mashhad branch, islamic azad university, mashhad, ir iran zahra vafaeey innovative medical research center, department of biochemistry, mashhad branch, islamic azad university, mashhad, ir iran sima afsharnezhad innovative medical research center, department of biochemistry, mashhad branch, islamic azad university, mashhad, ir iran; innovative medical research center, department of biochemistry, mashhad branch, islamic azad university, p. o. box: 917751365, mashhad, ir iran. tel: +98-5112250041, fax: +98-5112250048

conclusions the outcome of this study is that the oca has no toxic effect on h9c2 cells. results the results showed that the percentage of survived cells amount of extract dilution ratio (1:4; 1:2; 1) were 80.4%; 79.6%, 77.5% respectively. analysis of statistical test results does not show any significant differences between the optical density of the extract dilutions, and the control group in...

Journal: :journal of dental school, shahid beheshti university of medical sciences 0
فریال طالقانی ferial taleghani dental school, shahed universityدانشکده دندانپزشکی، دانشگاه شاهد. رویا یارایی roya yaraii dental school, shahed universityدانشکده دندانپزشکی، دانشگاه شاهد. رخساره صادقی rokhsareh sadeghi dental school, shahed universityدانشکده دندانپزشکی، دانشگاه شاهد. رزا حقگو roza haghgoo dental school, shahed universityدانشکده دندانپزشکی، دانشگاه شاهد. محمدباقر رضوانی mohammad bagher rezvani dental school, shahed universityدانشکده دندانپزشکی، دانشگاه شاهد.

objective: nanosilver has numerous applications in medicine due to its potent antibacterial activity. however, data regarding the bio-safety of its effective concentrations is scarce. this study aims to assess the toxicity of silver nanoparticles on human gingival epithelial cells under in-vitro conditions.   methods: this in vitro study evaluated the toxic effects of filtered and unfiltered na...

Journal: :avicenna journal of phytomedicine 0
amir zamiri-akhlaghi pharmacological research centre of medicinal plants, school of medicine, mashhad, university of medical sciences, mashhad, i. r. iran hasan rakhshandeh pharmacological research centre of medicinal plants, school of medicine, mashhad, university of medical sciences, mashhad, i. r. iran zahra tayarani-najaran pharmacological research centre of medicinal plants, school of medicine, mashhad, university of medical sciences, mashhad, i. r. iran seyed hadi mousavi medical toxicology research centre, school of medicine, mashhad university of medical sciences, mashhad, i. r. iran

objective: cancer is a major health problem worldwide and current therapies for cancer are often limited by short-term efficacy due to drug resistance. there has been much interest in the use of naturally occurring compounds with chemo-preventive and chemotherapeutic properties in the treatment of cancers. rose is one of the most important groups of ornamental plants which their fruits and flow...

Journal: :research in pharmaceutical sciences 0
s sahranavard f naghibi m mosaddegh s esmaeili p sarkhail m taghvaei

methanolic extract of 15 iranian medicinal plants were prepared and tested for their cytotoxic activities against three cancer cell lines (mcf7, hepg2 , wehi164) and one normal cell line (mdbk). some plants showed cytotoxic activities. the extract of ferula szowitsiana root, which proved to be the most active, was chosen for further phytochemical studies. the major compounds of the most potent ...

Journal: :asia pacific journal of medical toxicology 0
jalal pourahmad department of pharmacology and toxicology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (shahid beheshti university of medical sciences)

by discovering how chemical compounds/xenobiotics cytotoxicity is affected when their metabolic pathways are inhibited or activated, the metabolic pathways that activate versus detoxify chemical compound can be identified. reactive metabolites contributing to cytotoxicity can also be identified. in this lecture, the pretreatment of inhibitors and activators of xenobiotic metabolizing enzymes as...

Journal: :Journal of the mechanical behavior of biomedical materials 2011
H Fouad Rabeh Elleithy

The main objective of the present study is to investigate how the thermal, rheological, mechanical and cytotoxicity behavior of High Density Polyethylene (HDPE) can be changed by the addition of graphite nano particles (GNPs) at different contents. The HDPE/GNPs composites were prepared using melt blending in a co-rotating intermeshing twin screw extruder. The in vitro tests results showed that...

Journal: :Blood 1978
J Gmür A von Felten P Frick

Twenty-four thrombocytopenic patients refractory to random-donor platelet support were given 1 06 platelet transfusions obtamed from 57 different HLA-typed single donors. For critical evaluation of the transfusion responses, “fullhouse” HLA typing of donors and a precise measurement of the number of infused platelets were performed. Posttransfusion platelet increments were related to the HLA ma...

2015
Erman Salih Istifli Mehmet Topaktaş

This study aims to find the genotoxic and cytotoxic effects of a particular combination of pemetrexed (PMX) and cefixime (CFX) in human peripheral blood lymphocytes. Chromosome aberration (CA), sister chromatid exchange (SCE), and micronucleus (MN) tests were used to assess genotoxicity. Whereas, the cytotoxicity was evaluated by using mitotic index (MI), proliferation index (PI), and nuclear d...

2016
Camila Arruda Saldanha Mônica Pereira Garcia Diego Cesar Iocca Luciana Guilherme Rebelo Ana Camila Oliveira Souza Anamélia Lorenzetti Bocca Maria de Fátima Menezes Almeida Santos Paulo Cesar Morais Ricardo Bentes Azevedo

This study reports on in vitro and in vivo tests that sought to assess the antifungal activity of a newly developed magnetic carrier system comprising amphotericin B loaded onto the surface of pre-coated (with a double-layer of lauric acid) magnetite nanoparticles. The in vitro tests compared two drugs; i.e., this newly developed form and free amphotericin B. We found that this nanocomplex exhi...

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