Purpose: Developmental and/or epileptic encephalopathy with spike-and-wave activation in sleep (D/EE-SWAS) is a spectrum of conditions characterized by various phenotypes cognitive, linguistic, and behavioral regression associated sleep. We aimed to investigate the phenotypic treatment outcomes pediatric patients D/EE-SWAS.Methods: retrospectively analyzed medical records diagnosed D/EE-SWAS tr...

background: children with idiopathic thrombocytopenic purpura who are treated with intravenous immunoglobulin therapy might experience a decline in their absolute neutrophil count. the aim of this study was to investigate the incidence of neutropenia following intravenous immunoglobulin therapy in children with idiopathic thrombocytopenic purpura undergoing intravenous immunoglobulin therapy. p...

Lactate dehydrogenase (LDH) derived from rabbit muscle enhanced IgM production by human-human hybridoma HB4C5 cells 12.4-fold at 320 mug/ml under serum-free conditions. LDHs from pig muscle and pig heart also accelerated IgM production 8.4- and 6.4-fold, respectively. The immunoglobulin production stimulating activity of LDH was not accompanied by activation of cell proliferation. LDH from rabb...

1. Brannagan TH, Nagle KJ, Lange DJ, Rowland LP. Complications of intravenous immune globulin treatment in neurologic disease. Neurology 1996;47:674–677. 2. Silbert PL, Knezevic WV, Bridge DT. Cerebral infarction complicating intravenous immunoglobulin therapy for polyneuritis cranialis. Neurology 1992;42:257–258. 3. Woodruff RK, Grigg AP, Firkin FC, Smith IL. Fatal thrombotic events during tre...

Hairy cell leukemia (HCL) is caused by the proliferation and accumulation of morphologically characteristic cells whose cell line of origin (lymphocyte versus monocyte) has not been determined. In an attempt to determine the cell line from which these cells are derived. we studied the cells from the peripheral blood and spleens of 6 patients with HCL for their cytochemical. immunologic, surface...

RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal anti-D immunoglobulin. This management of HDN has proven to be one of the most successful cases of prophylactic treatment based on antibody ...

A two-year-old girl with fever, diarrhea and vomiting was presented to the Emergency Department (ED). maculopapular rash on face, cervical lymphadenopathy 1st degree dehydration were being noted. Laboratory results showed leukocytosis, neutrophilia a high level of C-reactive protein (CRP). Amoxicillin prescribed, but patient’s state did not improve. She returned ED all over her body 2nd dehydra...

OBJECTIVE The purpose of this study was to compare the efficacy and side effects of intravenous immunoglobulin (IVIG) with intravenous anti-D immunoglobulin for treatment of newly diagnosed acute childhood Idiopathic thrombocytopenic purpura (ITP). METHODS Children (6 months to 14 years) with newly diagnosed acute ITP and platelet count below 20,000/ microL were randomized to receive single d...

Another piece in the hypermutation puzzle Studies with transgenic mice are beginning to define the minimal requirements for the somatic hypermutation of immunoglobulin genes that is critical in the production of high-affinity antibodies. One of the hallmarks of an advanced vertebrate immune system is the ability of the body to remember an invading organism, and to educate itself to respond more...