We obtain a supergravity solution arising when D6-branes are wrapped on coassociative four-cycles of constant curvature in seven manifolds of G2 holonomy. The solutions preserve two supercharges and thus represent supergravity duals of three dimensional Yang-Mills with N = 1 supersymmetry. When uplifted to eleven dimensions our solution describes M-theory on the background of an eight manifold ...

PURPOSE the aim of our study was to assess the potential of combined intratendinous injection of an anti-angiogenic drug: bevacizumab (AA) and Platelet Rich Plasma (PRP) to treat tendinopathy in a murine model of patellar and Achilles tendinopathy, and to evaluate its local toxicity. MATERIAL AND METHOD twenty rats (80 patellar and Achilles tendons) were used for the study. We induced tendino...

Vangueria infausta burch subsp. infausta (Rubiaceae) produces fruits eaten by humans and animals. The leaf, fruit, stem bark and root bark are used as a remedy for many ailments and the roots are used to treat malaria. In this study, concentrations of fractions of the V. infausta root bark extract that produce 50% inhibition (IC50) are determined using the ability of the extract to inhibit the ...

The organosilicon compounds octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6) are high production volume chemicals that are widely used in household goods and personal care products. Due to their prevalence and chemical characteristics, cyclic siloxanes are being assessed as possible persistent organic pollutants. D4, D5, and D6 were me...

We discuss the lift of certain D6-antiD6-brane systems to M-theory. These are purely gravitational configurations with a bolt singularity. When reduced along a trivial circle, and for large bolt radius, the bolt is related to a nonsupersymmetric orbifold type of singularity where some closed string tachyons are expected in the twisted sectors. This is a kind of open-closed string duality that r...

We present our searches for the tubular bound states of a D2-brane with m D0-brane and n fundamental strings in the NS5-brane, Dp-brane or macroscopic strings backgrounds by solving the Dirac-Born-Infeld equation. The geometry of tubular configurations we considered are taken to be parallel to the background branes or macroscopic strings. The n fundamental strings therein may be the circular st...

The effective treatment of diseases of the nail remains an important unmet medical need, primarily because of poor drug delivery. To address this challenge, the diffusion, in real time, of topically applied chemicals into the human nail has been visualized and characterized using stimulated Raman scattering (SRS) microscopy. Deuterated water (D2O), propylene glycol (PG-d8), and dimethyl sulphox...

BACKGROUND The domestic pig currently indigenous to the Tibetan highlands is supposed to have been introduced during a continuous period of colonization by the ancestors of modern Tibetans. However, there is no direct genetic evidence of either the local origin or exotic migration of the Tibetan pig. METHODS AND FINDINGS We analyzed mtDNA hypervariable segment I (HVI) variation of 218 individ...

The fact that both the D6-brane and the orientifold 6-plane have smooth, horizon-free descriptions in M-theory makes them especially useful in understanding certain aspects of brane physics. We briefly review how this connection has been used to understand a number of effects, several of which are associated with the Hanany-Witten transition. One particular outcome is a ”confinement mod 2” effe...

Continuous exposure of cells to exogenous and endogenous agents produces many types of DNA damage during normal cell cycles. Post-replication repair, consisting of error-free and error-prone sub-pathways, is required for tolerance of such DNA damage. REV1 plays a crucial role in regulation of the error-prone pathway. To facilitate analysis of its cellular functions, we here generated a mouse Re...