We report a case of disseminated neuroblastoma (NB) causing epidural spinal cord compression in a 67-year-old woman. Because NB is primarily a tumor of infancy and childhood, less is known about its clinical course and optimal treatment in adults. This patient was treated with a thoracic laminectomy and tumor resection; polychemotherapy with one cycle of vindesine, cisplatin, and etoposide; one...

Menkinist and Tafinlar For Melanoma Two drugs made by GlaxoSmithKline—dabrafenib (Tafinlar) and trametinib (Mekinist)—have been approved for patients with metastatic or inoperable melanoma. The FDA also approved a companion diagnostic test (THxID, bioMerieux) for both agents to detect certain mutations in the BRAF gene that render melanoma cells susceptible to treatment with the drugs. The two ...

As a reflection of the considerable increase in the number of cancer patients treated with chemotherapy, indications for the use of implanted venous catheters are rapidly growing. However, in some cases, implanted venous catheters induce unwelcome complications. We herein report a rare case of septic pulmonary embolism (SPE) caused by local infection-associated catheter removal during the admin...

In the March 2009 edition of the European Respiratory Journal, KOSCHEL et al. [1] reported the case of a 54-yr-old female presenting with pneumonia associated with the use of temozolomide and whose clinical and radiographic presentation and anatomo–pathological signs were consistent with hypersensitivity pneumonitis. During the phase II trials preceding the marketing of this alkylating agent, w...

Malignant fibrous histiocytoma, usually seen in patients older than 10 years, is an aggressive soft-tissue sarcoma occurring mostly in the extremities and the trunk, but it is extremely rare in children. We report the clinical, radiological and pathologic features of a five-year-old boy who was diagnosed as a retroperitoneally originated malignant fibrous histiocytoma. The patient with unresect...

We describe a rare case of Castleman disease associated de novo with Hodgkin lymphoma. The incidence of Castleman disease is rare; only a few studies have described it in de novo association with Hodgkin lymphoma. The patient described here complained of unique evolutionary axillary adenopathy. A positron-emission tomography/computed tomography scan revealed hypermetabolic activity in this area...