Provoking plasticity of response of p53 involves mutations of the p53 gene within the further contextual accumulation of p53 protein within the cell cytoplasm. Activation of wild-type p53 gene and protein includes various post-translational modifications including specific phosphorylation and mutability performance of the core DNA binding domain in particular. Rigorous characterization and re-c...

Social insects offer exciting prospects for ageing research due to the striking differences in lifespan among castes, with queens living up to an order of magnitude longer than workers. A popular theory is that senescence is primarily the result of an accumulation of somatic damage with age, balanced by investment into processes of somatic maintenance. Investigation of these predictions in soci...

The damage accumulation condition expressed in terms of traction components on a physical plane is considered for both monotonic and cyclic loading conditions. The crack initiation is assumed to correspond to a critical value of damage parameter on a maximum damage plane. A non-local condition is formulated for singular stress or strain regimes. The model is applied to predict damage distributi...

Damage accumulation in living tissues occurs when the rate of damage formation is greater than the rate of damage repair. For very large increases in the loading rate of bones, this can result in "stress fractures" due to the growth and coalescence of fatigue related microdamage. At lower increases of loading rates, the damage accumulation process is halted because there is time for adaptive bo...

Plant metabolism and productivity is influenced adversely by salinity. Exogenous selenium (Se), applied as sodium selenate in biofortification programmes, has been found effective in alleviating the salt induced damage in plants. The study was conducted in order to determine the effects of exogenous Se supply (10 μM) on the resistance of lemon balm (Melissa officinalis L.) plants to salt stress...

The accumulation of cellular damage, including DNA damage, is thought to contribute to aging-related degenerative changes, but how damage drives aging is unknown. XFE progeroid syndrome is a disease of accelerated aging caused by a defect in DNA repair. NF-κB, a transcription factor activated by cellular damage and stress, has increased activity with aging and aging-related chronic diseases. To...

The disaccharide trehalose, which accumulates dramatically during heat shock and stationary phase in many organisms, enhances thermotolerance and reduces aggregation of denatured proteins. Here we report a new role for trehalose in protecting cells against oxygen radicals. Exposure of Saccharomyces cerevisiae to a mild heat shock (38 degrees C) or to a proteasome inhibitor (MG132) induced treha...

As a consequence of uromodulin gene mutations, individuals develop precocious hyperuricemia, gout, and progressive renal failure. In vitro studies suggest that pathologic accumulation of uromodulin/Tamm-Horsfall glycoprotein (THP) occurs in the endoplasmic reticulum (ER), but the pathophysiology of renal damage is unclear. It was hypothesized that programmed cell death triggered by accumulation...

ABSTRACT The fracture field of coal and rock mass is the main channel for gas migration accumulation. Exploring evolution law under condition drilling slitting construction has important theoretical significance guiding efficient drainage. generation process fissures also development accumulation its damage. Therefore, based on damage mechanics finite element theory, mathematical model establis...

An accumulation of evidence indicates the importance DNA damage signaling in modulating immune responses. Indeed, understanding mechanism that underlies signal transduction originating from is vital to overcoming refractory cancer, particularly when cancer therapy applied combination with damage-dependent radio/chemotherapy. In addition, immune-associated responses such signals can aggravate sy...