background :impact of substance abuse on outcome of hospitalized patients with acute myocardial infarction (mi) is a frequent question. available studies show disagreements over its impact, thus we performed this study to find a clear answer.   methods : in a cross sectional study, 304 patients (include 152 consecutive opium dependents and equal number of independents) with acute mi admitted to...

glutathione s-transferases (gsts; ec: 2.5.1.18) are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. functional genetic polymorphisms in genes encoding gstm1 (a member of gst class mu; omim: 138350), and gstt1 (a member of gst class theta; omim: 600436) have been well defined. the functional null alleles of gstm1 and gstt1 represent deletions of gstm1 and gs...

background and objective: today, opioids are used to control and relieve acute and chronic pain. however, the incidence of both tolerance and dependence phenomena for these drugs is a major problem. so, in this study, the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance was examined.    materials and methods: ninety-eight mic...

long-term exposure to opiates induces physical dependence and tolerance. the main goal of this study was to evaluate the effects of dextromethorphan and midazolam and their combination on morphine tolerance and dependence in mice. different groups of mice were rendered randomly and received morphine (50 mg/kg, sc), morphine (50 mg/kg, sc) + dextromethorphan (25,50 or 75 mg/kg, ip), morphine (50...

one of the most important behavioral aspects in relationship among the main members of marketing channel is the issue of power and dependence that here we have looked through the source of power and countervailing power and we have considered reputation independence, sale and profits and marketing role dependence. in this research relationship between the two main marketing channel members in h...

This paper contributes the analysis of the persistence of innovation activities, as measured by total factor productivity (TFP) and explores its internal and external determinants stressing its path dependent characteristics. The external conditions, namely the quality of local knowledge pools and the strength of the Schumpeterian rivalry, together with the internal conditions, that is the actu...