As a novel heat shock protein 90 inhibitor, AT-533 exhibits various biological activities in vitro, including anti-viral, anti-tumor and anti-inflammatory activities. Moreover, gel, gel dosage form of AT-533, has been suggested to have anti-keratitis herpes simplex virus type-1 infection-induced effects on the skin lesions animals. However, safety evaluation has, best our knowledge, not examine...

Purpose: To further evaluate the safety of Fuganlin Oral Liquid (FGLOL) for clinical application by conducting toxicological tests in young rats.
 Methods: Based on dose infants aged less than 1 year, 4-day-old Sprague-Dawley (SD) rats were orally administered FGLOL3.88, 11.64 and 38.75 g crude drug/kg 18 days, followed a 3-week withdrawal. This was evaluating effect FGLOL various growth d...

In this study, Corynebacterium kutscheri infection was reported in Sprague-Dawley rats that were stressed due to intense exercise during an experimental study. Weight loss, indifference the environment, fluffy feathers, and hunched posture observed affected rats. The lungs contained numerous, randomly distributed, variably sized, slightly raised, cream-colored caseopurulent foci. There occasion...