Rapidly restoring blood flow in the epicardial coronary artery after an acute obstruction is critical for limiting myocardial tissue damage and salvaging the area at risk. Minimizing the acute injury to the myocardium after an ischemic event (ie, infarct size) has been strongly correlated with improved outcome. In fact, large myocardial infarctions (MIs) have been associated with pronounced adv...

Rapidly restoring blood flow in the epicardial coronary artery after an acute obstruction is critical for limiting myocardial tissue damage and salvaging the area at risk. Minimizing the acute injury to the myocardium after an ischemic event (ie, infarct size) has been strongly correlated with improved outcome. In fact, large myocardial infarctions (MIs) have been associated with pronounced adv...

Hamster hearts transplanted into transiently complement-depleted and continuously cyclosporin A (CyA)-immunosuppressed rats survive long-term despite deposition of anti-donor IgM Abs and complement on the graft vascular endothelium. This phenomenon is referred to as "accommodation." The hypothesis tested here is that accommodated xenografts are resistant to IgM Abs and complement that could res...

in the present paper, the deformation zone of the ecae (equal channel angular extrusion) process was investigated using the upper bound theorem. for this purpose, the shape of the streamlines in the deformation zone was assumed to be cubic bezier curves. then, the force required for the ecae process was optimized with regard to the parameters defining the shape of streamlines by the upper bound...

abstract the objective of this study is evaluation of government’s optimum combination of policy instruments on per capita consumption of bread and the share of this product in food cost of families in different income classes. the minimization of changes in dead weight loss function is used in this study. by using boot strop method and on base of normal distribution for supply elasticity and d...

Aging hearts are known to have diminished capacity to be protected against reoxygenation ischemia/reperfusion (IR) injury provided by various cardioprotective regimens. In search of a more successful regimen, we have studied the response of aged hearts to preconditioning (PC) and postconditioning (POST) elicited by sphingosine or sphingosine 1-phosphate treatment.An ex vivo rat heart model was ...

This study tested the hypothesis that combination ion channel blockers of the transient outward current (I(to)) and the rapid component of the delayed rectifying current (I(Kr)) would produce greater prolongation of the ventricular action potential duration (APD) and increased dispersion of the APD in hypertrophied hearts compared with control hearts. Isolated rabbit hearts were studied 48 +/- ...

The interrelation between the rates of the innervated recipient heart and the denervated donor heart at rest, on standing, and during the different phases of maximal exercise was studied in nine patients 1-6 months after heterotopic cardiac transplantation. The resting heart rate was significantly higher in the donor heart compared with the recipient heart. Eight of the nine recipient hearts an...

OBJECTIVES We sought to determine whether improving coupling between glucose oxidation and glycolysis by stimulating glucose oxidation during reperfusion enhances postischemic recovery of hypertrophied hearts. BACKGROUND Low rates of glucose oxidation and high glycolytic rates are associated with greater postischemic dysfunction of hypertrophied as compared with nonhypertrophied hearts. MET...

BACKGROUND When shared by people who inject drugs, needles and syringes with different dead space may affect the probability of HIV and hepatitis C virus (HCV) transmission differently. METHODS We measured dead space in 56 needle and syringe combinations obtained from needle and syringe programs across 17 countries in Europe and Asia. We also calculated the amounts of blood and HIV that would...