BACKGROUND AND OBJECTIVES High levels of factor VIII are a common risk factor for venous thromboembolism (VTE). The aim of this study was to evaluate the possible interaction between the presence of high factor VIII levels and oral contraceptive (OC) use. DESIGN AND METHODS Factor VIII levels were measured by a chromogenic assay in 174 women who suffered from VTE in reproductive age and in 48...

INTRODUCTION: Thrombophilia is the increased tendency to form thrombi, often silent, usually due to genetic mutations. Venous thrombosis has an incidence of 0.1% in the general adult population. Deep vein thrombosis (DVT) with pulmonary emboli (PE), collectively called venous thromboembolism (VTE), can be fatal in up to 25% of patients with PE. Case review of two brothers with both familial mul...

OBJECTIVES To study the prevalence of factor V Leiden mutation in patients with chronic venous insufficiency and venous leg ulcers, compared with a control group, and to find out whether factor V Leiden mutation is more frequent in patients with chronic venous insufficiency and a history of deep venous thrombosis. DESIGN A case control study. SETTING Three outpatient dermatological clinics....

INTRODUCTION Current guidelines on venous thromboembolism (VTE) prevention do not reflect the potential varying risk for patients undergoing different urological procedures. Our study aimed to establish the procedure specific rate of postoperative VTE in patients undergoing urological surgery. METHODS Hospital Episode Statistics were obtained for all patients undergoing common urological pro...

OBJECTIVES The study hypothesis was that a target-specific anticoagulant would allow successful home treatment of selected patients with deep vein thrombosis (DVT) and pulmonary embolism (PE) diagnosed in two urban emergency departments (EDs). METHODS A protocol was established for treating low-risk DVT or PE patients with rivaroxaban and clinic, follow-up at both 2 to 5 weeks, and 3 to 6 mon...

INTRODUCTION: Thrombophilia is the increased tendency to form thrombi, often silent, usually due to genetic mutations. Venous thrombosis has an incidence of 0.1% in the general adult population. Deep vein thrombosis (DVT) with pulmonary emboli (PE), collectively called venous thromboembolism (VTE), can be fatal in up to 25% of patients with PE. Case review of two brothers with both familial mul...

10.2217/14750708.5.5.685 © 2 Dabigatran etexilate is a direct thrombin inhibitor that offers potential advantages over existing anticoagulants for the prevention and treatment of venous and arterial thrombosis. It is administered orally, has a rapid onset of action, a predictable anticoagulant effect and does not require laboratory monitoring. Trial results indicate that dabigatran etexilate ha...

Unicompartmental knee arthroplasty has been associated with faster recovery with less potential perioperative morbidity compared to total knee arthroplasty. This study investigates the rate of transfusion, symptomatic thromboembolic events, and length of hospital stay in 1000 consecutive, unicompartmental knee replacements performed by 2 surgeons. A rapid recovery protocol coupled with multimod...

EDUCATIONAL OBJECTIVES As a result of reading this article, physicians should be able to: 1. Recognize the high risk of postoperative venous thromboembolism (VTE) in patients undergoing major orthopedic surgery. 2. Distinguish the different pharmacological mechanisms of VTE prophylaxis drugs. 3. Delineate the advantages and disadvantages of each VTE prophylaxis drug. 4. Recognize that rivaroxab...

IntroductIon Venous thromboembolism (VTE) is a systemic and potentially lethal illness. It consists of two related clinical manifestations: Pulmonary thromboembolism (PTE) and deep venous thrombosis (DVT).[1,2] DVT of the lower extremities is believed to be the source of PTE in most patients, and the primary risk factor for recurrent PTE is the presence of residual proximal venous thrombosis. P...