نتایج جستجو برای: dendritic structure

تعداد نتایج: 1615344  

Journal: :Methods 2003
Alfredo Rodriguez Douglas Ehlenberger Kevin Kelliher Michael Einstein Scott C Henderson John H Morrison Patrick R Hof Susan L Wearne

Experimental and theoretical studies demonstrate that both global dendritic branching topology and fine spine geometry are crucial determinants of neuronal function, its plasticity and pathology. Importantly, simulation studies indicate that the interaction between local and global morphologic properties is pivotal in determining dendritic information processing and the induction of synapse-spe...

Journal: :Cerebral cortex 2006
Yasuo Kawaguchi Fuyuki Karube Yoshiyuki Kubota

To understand the dendritic differentiation in various types of cortical nonpyramidal cells, we analyzed quantitatively their dendritic branching and spine expression. The dendritic internode and interspine interval obeyed exponential distributions with type-specific decay constants. The initial branching pattern, internode interval and spine density at the light microscopic level divided nonpy...

2016
Mary Ann Go Julian Min Chiang Choy Alexandru Serban Colibaba Stephen Redman Hans-A. Bachor Christian Stricker Vincent Ricardo Daria

Neurons are classified according to action potential firing in response to current injection. While such firing patterns are shaped by the composition and distribution of ion channels, modelling studies suggest that the geometry of dendritic branches also influences temporal firing patterns. Verifying this link is crucial to understanding how neurons transform their inputs to output but has so ...

2011
Sonya B. Dumanis Hyun-Jung Cha Jung Min Song Justin H. Trotter Matthew Spitzer Ji-Yun Lee Edwin J. Weeber R. Scott Turner Daniel T. S. Pak G. William Rebeck Hyang-Sook Hoe

BACKGROUND Apolipoprotein E receptor 2 (ApoEr2) is a postsynaptic protein involved in long-term potentiation (LTP), learning, and memory through unknown mechanisms. We examined the biological effects of ApoEr2 on synapse and dendritic spine formation-processes critical for learning and memory. METHODOLOGY/PRINCIPAL FINDINGS In a heterologous co-culture synapse assay, overexpression of ApoEr2 ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Andrew M Tan Omar A Samad Tanya Z Fischer Peng Zhao Anna-Karin Persson Stephen G Waxman

Diabetic neuropathic pain imposes a huge burden on individuals and society, and represents a major public health problem. Despite aggressive efforts, diabetic neuropathic pain is generally refractory to available clinical treatments. A structure-function link between maladaptive dendritic spine plasticity and pain has been demonstrated previously in CNS and PNS injury models of neuropathic pain...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Rana N El-Danaf Andrew D Huberman

Retinal ganglion cell (RGC) loss is a hallmark of glaucoma and the second leading cause of blindness worldwide. The type and timing of cellular changes leading to RGC loss in glaucoma remain incompletely understood, including whether specific RGC subtypes are preferentially impacted at early stages of this disease. Here we applied the microbead occlusion model of glaucoma to different transgeni...

Journal: :international journal of nano dimension 0
ramadoss karthikeyan department of biotechnology, acharya nagarjuna university, nagarjuna nagar, guntur-522510 india. palanirajan vijayraj kumar faulty of pharmaceutical sciences, ucsi university, kualalampur, malaysia. oruganti sai koushik vignan pharmacy college, vadlamudi – 522213, india.

pegylated polypropyleneimine (ppi) dendritic scaffold was used for the delivery of an anti-leukemic drug, imatinib. the current study evolves and emerges the use pegylated ppi dendritic scaffold for the delivery of this drug. in this imatinib was synthesized and loaded with pegylated ppi dendritic scaffold. parameters such as ft-ir, nmr, sem, drug release, dsc and hemolytictoxicity are required...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت دبیر شهید رجایی - دانشکده علوم پایه 1392

یک فضای خطی متناهی بر v نقطه با b خط یک فضا است که در آن از هر دو نقطه درست یک خط عبور می کند. در این پایان نامه ما مقالات زیر را که مربوط به فضاهای خطی ایت را بررسی می کنیم. melone, n. (1991). a structure theorem for finite linear spaces. lecture notes math, 2, 231-241. bridges, w.g. (1972). near 1-designs. j. combinatorial theory (a), 13, 116-126. varga, l.e. (1985). a note on the structu...

2010
Michael J. Schachter Nicholas Oesch Robert G. Smith W. Rowland Taylor

The On-Off direction-selective ganglion cell (DSGC) in mammalian retinas responds most strongly to a stimulus moving in a specific direction. The DSGC initiates spikes in its dendritic tree, which are thought to propagate to the soma with high probability. Both dendritic and somatic spikes in the DSGC display strong directional tuning, whereas somatic PSPs (postsynaptic potentials) are only wea...

Journal: :The Journal of experimental biology 1984
J P Miller G A Jacobs

The geometry and electrical properties of a neurone determine how synaptic inputs and endogenously generated currents are integrated and transformed into the signals it transmits to other cells. The dependence of neuronal integration upon dendritic geometry has been studied extensively over the last three decades, both by experimentalists and by theoreticians. We review some of the general prin...

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