Introduction: The main aim during any dental treatment is to maintain vital pulp as long as possible. Objective: The aim of this study was to assess clinically the use of MTA in direct pulp capping in adult patient. Method: MTA was performed in two visits treatment protocol on direct pulp capping in adult. Results: Clinical and radiological examination conducted after 7 months post treatment of...

To heal or not to heal? Chemokines as determinants of constructive or destructive inflammatory microenvironments Dear Readers, Dental pulp stem cells gained attention as a subpopulation of postnatal stem cells with the ability of multipotential differentiation. Therefore, these cells, specifically SHED (stem cells from human exfoliated deciduous teeth), have been extensively investigated as a p...

endodontic intervention in necrotic immature permanent teeth is usually a clinical challenge. with appropriate case selection, regenerative treatment can be effective, providing a desirable outcome. however, there is still no consensus on the optimal disinfection protocol or the method to achieve predictable clinical outcome. this article presents two cases of regenerative treatment in necrotic...

Exogenous ideal delivery system for biologically active molecules is under intensive investigation. In the present study it was aimed to test the availability of different calcium phosphate biomaterials (CPBs), hydroxyapatite (HA), beta tricalcium phosphate (TCP), and a combination of these (TCP+HA) as dental pulp capping systems on healing of dog dental pulp. Experimentally perforated dental p...

Predictable pulp capping procedures remain problematic, possibly because of the lack of appropriate stimulating factors for dentin formation. The present study examines the ability of one such stimulating factor, bone morphogenetic protein-2, to accelerate the differentiation of human dental pulp cells into odontoblasts. The number and morphology of cells between groups treated with 0 and 100 n...

Stem cells have been successfully isolated from a variety of human and animal tissues, including dental pulp. This achievement marks progress in regenerative dentistry. This article reviews the latest improvements made in regenerative dental medicine with the involvement of stem cells. Although, various types of multipotent somatic cells can be applied in dentistry, two types of cells have been...

the purpose of this review is to gain an overview of the applications of the dental pulp stem cells (dpscs) in the treatment of various medical diseases. stem cells have the capacity to differentiate and regenerate into various tissues. dpscs are the adult   stem cells that reside in the cell rich zone of the dental pulp. these are the multipotent cells that can be explained by their embryonic ...

* Assistant Professor, College of Dental Surgery, B.P. Koirala Institute of Health Sciences, Dharan, Nepal ** Bacteriologist, Govt Medical College and Hospital, Patiala, Punjab, India INTRODUCTION Periapical pathosis is considered as an endogenous infection caused by oral microflora. Bacterial infection of dental pulp results in pulpal destruction and subsequently stimulates an inflammatory cel...

ATP-dependent profiles of phosphofructokinase (PFK) activity were determined in both crude and Sephadex G-25-filtered fractions from rabbit dental pulp. ATP had a dual effect on PFK as an activator and an inhibitor, according to its concentration. Gel-filtered PFK showed a similar profile to that of crude PFK, indicating a lack of low-molecular-weight effector(s) for PFK in rabbit dental pulp. ...

We previously reported that miR-183 was downregulated during the direct conversion of dental pulp cells to insulin-producing cells. To further elucidate the role of miRNA regulation in dental pulp cells during this process, we examined the eff ect of miR-183 inhibition. Insulin expression was detected in induced cells 72 hours after ectopic expression of miR-183 inhibitor. The expression levels...