BACKGROUND Our previous pharmacological and cellular studies showed that peripheral (cardiac and vascular) nitric oxide synthase (NOS)-derived NO is implicated in the estrogen (E(2))-dependent hypotensive action of ethanol in female rats. The objective of this study was to test the hypothesis that enhanced NO production in the nucleus tractus solitarius (NTS) is implicated in the E(2)-dependent...

Abstract We previously developed a triazole modified tetraiodothyroacetic acid (TAT) conjugated to polyethylene glycol (PEG)-based thyrointegrin αvβ3 antagonist targeted compound, called P-bi-TAT. It exhibited potent anti-angiogenic and anticancer activities in vivo. The objective of the current study is develop quantitative bioanalytical method for P-bi-TAT using liquid chromatography-tandem m...

Abstract Background Cognitive impairment is one of the common comorbidities in patients with temporal lobe epilepsy (TLE), but underlying mechanisms remain largely unknown. Previous studies have found significant decay hippocampal long-term potentiation (LTP) TLE rats cognitive impairment. As activation α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) responsible for LTP...

background and aims. the aim of the present study was to compare the inhibitory effects of two systemic doses of hesa-a on prevention of 4-nqo-induced tongue neoplasms in rats. this study evaluated weight and histopathological changes. materials and methods. forty-eight male sprague dawley rats were divided into four groups of a, b, c and d of each 12 rats. the rats in groups b to d received 30...

Primary and secondary hypertension is associated with kidney redox imbalance resulting in enhanced reactive oxygen species (ROS) and enzymes dependent phospholipid metabolism. The fatty acid amide hydrolase inhibitor, URB597, modulates the levels of endocannabinoids, particularly of anandamide, which is responsible for controlling blood pressure and regulating redox balance. Therefore, this stu...

The correlation between the development of barbital (B)-withdrawal signs and alterations in the metabolism of brain 5-hydroxytryptamine (5-HT) was studied. Barbital (B)-dependent rats were prepared by the B-Admixed Food method (DAF method). The B-dependent rats were grouped according to the following 5 states: G-I, B-dependent state; G-II, B-withdrawn state; G-III, cross-administration of nitra...

The strain and sex differences in serum total cholesterol (TC) levels were examined in F344 and Sprague-Dawley (SD) rats. A sex difference (male<female) was observed in F344 rats but not in SD rats. The strain-dependent sex difference (male<female) was also observed in the constitutive gene expression level of hepatic 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR), a rate-limiting enzyme for ...

The aqueous extract of Syzygium cumini (Pulp) was investigated for its possible hypoglycemic and antioxidant potentials in streptozotocin (STZ) induced diabetic wistar female rats. A single intraperitoneal injection of STZ at a dose of 55 mg/kg body weight elevated the glucose levels more than 230 mg/dl after 3 days. Treatment with the aqueous extract of Syzygium cumini (Pulp) at 100 mg/kg ...

BACKGROUND The plant-derived estrogen biochanin A is known to cause vasodilation, but its mechanism of action in hypertension remains unclear. This study was undertaken to investigate the effects and mechanisms of biochanin A on the thoracic aorta in two-kidney, one clip (2K1C) renovascular hypertensive rats. METHODS Hypertension was induced by clipping the left renal artery, and control age-...