Genome-wide association studies (GWAS) have been successful in finding associations between specific genetic variants and cancer susceptibility in human populations. These studies have identified a range of highly statistically significant associations between single nucleotide polymorphisms (SNPs) and susceptibility to development of a range of human tumors. However, the effect of each SNP in ...

BACKGROUND Drugs such as isoniazid (INH) and pretomanid (PRT), used against Mycobacterium tuberculosis are active partly through generation of reactive nitrogen species (RNS). The aim of this study was to explore variability in intracellular susceptibility to nitric oxide (NO) in clinical strains of M. tuberculosis. METHOD Luciferase-expressing clinical M. tuberculosis strains with or without...

HLA-A, B, C, and DR-typing was performed in 51 children with insulin-dependent diabetes. A close association between childhood diabetes and HLA-DR3 and DR4 was established. DR3 was found in 55% and DR4 in 75% of the diabetic children, compared with 20% and 26% respectively in healthy controls. The combination of DR3 and DR4 was present in 37% of the diabetic children compared with only 4% of th...

We report on the synthesis and physical properties of cm-sized CoGeO3 single crystals grown in a high pressure mirror furnace at pressures 80 bar. Direction dependent magnetic susceptibility measurements our reveal highly anisotropic that we attribute to impact strong ion anisotropy appearing this system with TN∼33.5 K. Furthermore, observe effective moments are exceeding spin only values Co io...

introduction: stenotrophomonas maltophilia is a nosocomial multi drug resistant opportunistic pathogen which causes infections in vulnerable patients with cancer, cystic fibrosis and indwelling catheters. methods: 45 clinical s. maltophilia isolates were collected from blood samples and identified by biochemical tests. susceptibility to different antibiotics including co-trimoxazole, levofloxac...

background urinary tract infection (uti) is one of the most common bacterial diseasesworldwidethat can be presented asymptomatic or symptomatic, characterized by a wide range of symptoms from mild irritative voiding to bacteremia, sepsis, or even death. in latter decades, widespread utilization of antibiotics has resulted in increased incidence of antibiotic resistance among urinary tract patho...

The properties of ${\mathrm{RbBi}}_{2}$, a 4.15 K superconductor, were investigated using magnetic field, pressure, and neutron diffraction. Under hydrostatic an almost 50% reduction ${T}_{c}$ is observed, linked to low Debye temperature estimated at 165 K. resistivity susceptibility measured on quenched slow-cooled polycrystalline samples. follows power-law dependence in both types samples, wh...