In this study we have performed genome-wide analysis to identify Nkx2-5 binding regions using mid-gestation mouse hearts to gain insight into the molecular mechanisms by which Nkx2-5 contributes to the correct development of the heart. Nkx2-5 and SRF invivo binding sites were mapped using ChIPchip assays and analysis of the ChIP-chip data has identified 600 and 858 SRF and Nkx2-5-binding sites,...

This paper mainly describes the way that using (multiple chip module)MCM technology to optimize and improve design of small satellite's electronic system from application requirement view. Research on MCM based on Silicon wafer is carried out, combined with software and IC integration technology. Finally, the ultimate realization is Miniaturization, integration, standardization of the design of...

RATIONALE The number of patients with coronary heart disease, including myocardial infarction, is increasing and novel therapeutic strategy is awaited. Tumor suppressor protein p53 accumulates in the myocardium after myocardial infarction, causes apoptosis of cardiomyocytes, and plays an important role in the progression into heart failure. OBJECTIVES We investigated the molecular mechanisms ...

Starr is an extension of the Ringo [6] package for the analysis of ChIP-chip projects. Whereas the latter is specialized to the processing of Nimblegen and Agilent arrays, the former provides all corresponding features for Affymetrix arrays. Data can be read in from Affymetrix CEL-files, or from text files in gff format. Standard quality assessment and data normalization tools are available. St...

we design and simulate a five-port optical router, which is composed of twenty mach-zehnder-based switching elements and twelve waveguide crossings for use in integrated photonic interconnection networks. we simulated and analyzed the operation of the proposed optical router from the aspects of insertion loss, power budget, q-factor and the minimum bit error ratio by use of optisystem simulator...

Performance analysis plays an essential role in achieving a scalable performance of applications on massively parallel supercomputers equipped with thousands processors. This paper is empirical investigation to study, depth, the two most common High-Performance Computing architectures world. IBM has developed three generations Blue Gene supercomputers—Blue Gene/L, P, and Q—that use, at large sc...

There have been ample successful examples of applying Xilinx Vivado’s “function-to-module” high-level synthesis (HLS) where the subject is algorithmic in nature. In this work, we carried out a design study to assess the effectiveness of applying Vivado-HLS in structural design. We employed Vivado-HLS to synthesize C functions corresponding to standalone network-on-chip (NoC) routers as well as ...

Network-on-Chip (NOC) has been proposed as an attractive alternative to traditional dedicated wire to achieve high performance and modularity. Power and Area efficiency is the most important concern in NOC design. Small optimizations in NoC router architecture can show a significant improvement in the overall performance of NoC based systems. Power consumption, area overhead and the entire NoC ...

BACKGROUND Ultrasound transient elastography technology has found its place in elastography because it is safe and easy to operate. However, it's application in deep tissue is limited. The aim of this study is to design an ultrasound transient elastography system with coded excitation to obtain greater detection depth. METHODS The ultrasound transient elastography system requires tissue vibra...