Saccharin, a synthetic sweetener constituent of several pharmaceutical and cosmetic preparations, is analyzed qualitatively and quantitatively in the presence of interferences like active ingredients and excipients. A derivative ultraviolet spectrophotometric method employing the second and the fourth orders was used. The calibration data obtained were satisfactory, with a relative precision ra...

Two simple and rapid spectrophotometric methods were developed for the determination of two binary mixtures: moxifloxacin hydrochloride (MFH) with ketorolac tromethamine (KTM) and ciprofloxacin hydrochloride (CFH) with dexamethasone sodium phosphate (DSP). The first method, zero-crossing derivative spectrophotometry, depends on measuring the second derivative peak and trough values at 304 nm an...

a mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. in this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. determination of these drugs was perf...

Canonical forms are given for the nilpotent BRS operator δ and the covariant ‘loop space’ derivative Dμ for the p-brane fields for all odd p. The defining characteristic of Dμ is that it is a functional derivative operator which generalizes the ordinary functional derivative and also commutes with δ. Methods of construction for the canonical forms are discussed.

We develop a non-anticipative calculus for functionals of a continuous semimartingale, using an extension of the Ito formula to path-dependent functionals which possess certain directional derivatives. The construction is based on a pathwise derivative, introduced by B Dupire, for functionals on the space of right-continuous functions with left limits. We show that this functional derivative ad...

Objective: Four different methods were used for stability indicating determination of aripiprazole in presence of its oxidation product in pure and its dosage form. Methods: The described methods are namely, second derivative spectrophotometry, first-derivative of ratio spectra; bivariate and thin layer chromatography. Results: The derivative spectrophotometric method was based on measuring the...