BDNF (Brain derived neurotrophic factor) is a secretion protein and a member of the neurotrophin family of growth factors. Structural and functional characterization of BDNF Varanus komodoensis is of interest while its structure remains unknown. Thus, a homology molecular model of BDNF was constructed for gleaning possible structural insights. The model was compared with the structure of the ho...

During the past decade, 3ʹ untranslated regions (3ʹUTRs) of mRNAs continue to emerge as important sites for gene regulation due to the binding of microRNAs (miRs), RNA-binding proteins (RBPs) and possibly other trans-acting factors. Brain derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) play important roles inside and outside the central nervous system (...

Dementia involves several factors, and it is required to administer an agent with efficiencies for its treatment. Sake known have antioxidant anti-inflammatory properties improves the serum concentration of BDNF. This study aimed evaluate neuroprotective action Japanese sake yeast on dementia Alzheimer disease type in rats by behavioral evaluation neurobiochemical assessment. The were grouped a...

Despite intensive research effort, no effective pharmacological therapies for Parkinson’s disease (PD) have been developed. However, with the development of efficient gene delivery systems, gene therapy for PD has become a focus of research, and increasing evidences suggest that continuous production of neurotrophic factors plays a significant role in the functional restoration of the nigrostri...

Trauma and loss of cochlear inner hair cells causes a series of events that result first in the retraction of the peripheral processes of the auditory nerve, scar formation in the organ of Corti, and over the course of weeks to months (depending on the species) the loss of auditory nerve cell bodies (spiral ganglion cells). Neurotrophic factors play an important role in the mature nervous syste...

Rationale: Oxidative stress in rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons for the maintenance of neurogenic vasomotor tone are located, contributes to neural mechanisms of hypertension. Emerging evidence suggests that brain-derived neurotrophic factor (BDNF) manifests " nontrophic " actions. Objective: We assessed the hypothesis that BDNF plays an active role in ox...

Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function the peripheral central nervous system. It is well known that a variety of intracellular signaling stimulated by TrkB, high-affinity receptor for involved physiological pathological aspects via affecting viability, function, neurogenesis, cognitiv...

There is growing evidence for extensive interaction between sensory neurons, immune and mucosal epithelial cells during airway inflammation and hyperreactivity. This neuro-immune cross-talk (neurogenic inflammation) involves different groups of mediators, which include the neurotrophin family (nerve growth factor, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 and -4). Neurotrophin...

Many experimental data support the enhancement of neurotrophic factors as a means to modify neurodegeneration in Parkinson's disease. However, the translation of this to the clinic has proven problematic. This is likely due to the complex nature of the surgical gene delivery and cell-based approaches adopted to deliver proteinaceous neurotrophic factors to targets within the central nervous sys...

TrkB is a high affinity receptor for the brain derived neurotrophic factor (BDNF) and its phosphorylation stimulates activation of several intracellular signalling pathways linked to cellular growth, differentiation and maintenance. Identification of various activators and inhibitors of the TrkB receptor and greater understanding their binding mechanisms is critical to elucidate the biochemical...