نتایج جستجو برای: derived neurotrophin
تعداد نتایج: 484034 فیلتر نتایج به سال:
Expression of the neurotrophin-3 receptor, tyrosine kinase C (TrkC), is associated with favorable prognosis in medulloblastoma patients. This may be due to increased tumor apoptosis induced by TrkC activation. Neurotrophin-3/TrkC-induced apoptosis is inhibited by the mitogen-activated protein (MAP) kinase (MAPK) pharmacologic antagonists SB203580 and PD98059. In addition to extracellular signal...
The present study uniquely combines olfactory ensheathing glia (OEG) implantation with ex vivo adenoviral (AdV) vector-based neurotrophin gene therapy in an attempt to enhance regeneration after cervical spinal cord injury. Primary OEG were transduced with AdV vectors encoding rat brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or bacterial marker protein beta-galactosidase (La...
We have found that stem cell factor (SCF) selectively enhances the survival of cultured embryonic chick dorsal root ganglia (DRG) neurons. Neurons grown in the presence of SCF expressed both neurofilament 150 kDa subunit and calcitonin-gene related peptide. SCF does not, however, enhance the survival of parasympathetic, placode-derived sensory or sympathetic neurons in culture. Combining SCF wi...
Trophic factors play an important role in the development of neurons and glia. In order to study the involvement of neurotrophins in human cortical development, human fetal parietal cortical tissue, obtained after early elective abortions, was transplanted to cortical cavities in immunosuppressed rats. Using in situ hybridization it was demonstrated that nerve growth factor, brain-derived neuro...
In many areas of the nervous system, excitatory and inhibitory synapses are reconfigured during early development. We have previously described the anatomical refinement of an inhibitory projection from the medial nucleus of the trapezoid body to the lateral superior olive in the developing gerbil auditory brain stem. Furthermore, these inhibitory synapses display an age-dependent form of long-...
Light information reaches the suprachiasmatic nucleus (SCN) through a subpopulation of retinal ganglion cells. Previous work raised the possibility that brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related receptor kinase may be important as modulators of this excitatory input into the SCN. In order to test this possibility, we used whole-cell patch-clamp methods t...
Recovery from spinal cord injury (SCI) after mesenchymal stem cells (MSCs) implantation is minimal due to the limited capacity for the reduction in the cystic cavitation, the axonal regeneration, and neural plasticity in the spinal cord. We combined MSC implantation with neurotrophin gene therapy in an attempt to enhance regeneration and functional recovery after thoracic spinal cord complete i...
Neurotrophins are a unique family of polypeptide growth factors that influence the proliferation, differentiation, survival and death of neuronal and non-neuronal cells. They are essential for the health and well-being of the nervous system. NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), NT-3 (neurotrophin-3) and NT-4 (neurotrophin-4) also mediate additional higher-order a...
The nuclear protein poly(ADP-ribose) polymerase-1 (PARP-1) is activated in response to DNA nicks and thus promotes DNA repair. The addition of ADP-riboses to acidic amino acid residues modifies the chromatin structure and affects DNA transcription and repair. This week, Visochek et al. provide data indicating that neurotrophins can also trigger PARP-1 activation. Brief exposures of cultured cor...
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