Sulphur mustard (SM), chemically bis (2-chloroethyl) sulphide is a bifunctional alkylating agent that causes cutaneous blisters in human or animals. There is no specific therapy for SM induced skin injury, however, DRDE/WH-02 (containing PVP-I, Aloe vera gel and betaine) has proved to be an effective remedy for SM dermatotoxicity in preclinical studies. This study was planned to evaluate safety...

background: considering the common origin of skin and peripheral nervous system, a tube of dermal layer of skin hypothetically can be an ideal conduit for nerve reconstruction. an experimental study performed to evaluate the nerve regeneration of efficacy into a dermal tube. methods: sixty male wistar rats were used. a 10 mm gap was produced in right sciatic nerves. in group a the autogenous ne...

Tin(IV) oxide functions as an abrasive, bulking, and opacifying agent in cosmetic products and is used at concentrations up to 0.4% in rinse-off products and up to 1.3% in leave-on products. The Cosmetic Ingredient Review Expert Panel (Panel) noted that tin(IV) oxide is a water-insoluble inorganic metal compound and should not be percutaneously absorbed; therefore, systemic exposure is not like...

Cytotoxicity of depleted uranium, as a byproduct of military has been came to spotlight in recent decades. DU is known as a chemical rather than radioactive hazard and efforts to illustrating its mechanism is undergo, but the precise complete molecular mechanisms are still unclear. Recent studies showed that uranium induces biological changes in many different target tissues, such as the kidney...

Isobutylene has a low order of acute toxicity. As isobutylene is a gas at normal temperature and pressure, ingestion or dermal absorption of this material is unlikely. The 2-hour LC50 of isobutylene in mice was 180,000 ppm (415 mg/L) and the 4-hour LC50 in rats was 270,000 ppm (620 mg/L). Inhalation of isobutylene can produce central nervous system depression, anesthesia and/or asphyxiation. Ho...

Pemetrexed is approved to treat non-small cell lung cancer and has an overall favorable toxicity profile. We describe a 58-year-old man who developped an anaphylactic shock within few minutes from the beginning of pemetrexed perfusion. Pemetrexed was discontinued and the patient's symptoms gradually resolved with administration of symptomatic treatment. Serum tryptase level remained normal and ...

Catechols were synthesized from safrole. Nine derivatives were prepared and assessed for antiproliferative effects using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. The derivatives 4-allylbenzene-1,2-diol (3), 4 4-[3-(acetyloxy)propyl]-1,2-phenylene diacetate (6) and 4-[3-(acetyloxy)propyl]-5-nitro-1,2-phenyle...

Polymeric hydrogels are used as wound dressing material since these materials show advantages such as pain relief, exudates absorption, barrier to microorganisms, permeability, and others. This article shows the results obtained in a study aiming to know the biological performance of different polymeric materials to be used in contact with skin: PVP hydrogels and acrylate adhesive. The biocompa...

rd HJ. Reverse dosimetry: interpreting trihalomethanes biomonitoring data using physiologically based pharmacokinetic modeling. Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform. et al. Bladder cancer and exposure to water disinfection by-products through ingestion, bathing, showering, and swimming in pools. AD. Th...