Mannheimia haemolytica infection results in enhanced PMN-mediated tissue damage in the lungs of bighorn sheep (BHS) compared to that of domestic sheep (DS). SERPIN B1 is an inhibitor of PMN-derived serine proteases. It prevents lung tissue injury by inhibiting the serine proteases released as a result of PMN lysis and degranulation. It is conceivable that PMNs of BHS exhibit decreased quantity ...

DtmING A STUDY concerning the role of vitamin B1, in diabetes (1), it was noted that a number of cases in this study failed to excrete more than 10 gig. of a 50Lg. intramuscular load dose of the vitamin. All of these patients had a history of liver disease or some form of hepatic insufficiency. The storage of vitamin B1, by the liver has been studied extensively by Meyer et at. (2) and by Glass...

We previously demonstrated that B1 induced significant cytotoxic effects, cell cycle G1 arrest and apoptosis in human lung cancer A549 cells through the inhibition of DNA topoisomerase II activity. In the present study, we focused on the histone deacetylase (HDAC) modulation of B1 in A549 cells. HDACs, important enzymes affecting epigenetic regulation, play a crucial role in human carcinogenesi...

PURPOSE Betulinic acid, a naturally occurring pentacyclic triterpenoid, exhibits potent antitumor activities, whereas the underlying mechanisms remain unclear. In the current study, we sought to determine the role and regulation of lamin B1 expression in human pancreatic cancer pathogenesis and betulinic acid-based therapy. EXPERIMENTAL DESIGN We used cDNA microarray to identify betulinic aci...

OBJECTIVES Aberrant expression of cyclin B1, a cell cycle regulator, is related to prognosis in various human malignancies. Additionally, cytoplasmic expression of cyclin B1 in epithelial malignancies is associated with a specific T-cell response and presumably also a humoral immune response. We therefore investigated (i) whether a similar expression pattern could be detected in native human ac...

Protein complex of cyclin B1 and cyclin-dependent protein kinase 1 induces phosphorylation of key substrates that mediate cell cycle transition during the G(2)-M phase. It is believed that cyclin B1 accumulates in the S phase of the cell cycle and reaches the maximal level at mitosis but is absent in G(1)-phase cells. In the present study, we demonstrated that cyclin B1 was expressed in the arr...

The joint use of multi-frequency signals brings new prospects for precise positioning and has become a trend in Global Navigation Satellite System (GNSS) development. However, a new type of inter-frequency clock bias (IFCB), namely the difference between satellite clocks computed with different ionospheric-free carrier phase combinations, was noticed. Consequently, the B1/B3 precise point posit...

Within the mammalian ovary, oocytes remain arrested at G2 for several years. Then a peri-ovulatory hormonal cue triggers meiotic resumption by releasing an inhibitory phosphorylation on the kinase Cdk1. G2 arrest, however, also requires control in the concentrations of the Cdk1-binding partner cyclin B1, a process achieved by anaphase-promoting complex (APC(Cdh1)) activity, which ubiquitylates ...

Lenstra, Lenstra, and Lovász in [7] proved several inequalities showing that the vectors in an LLL-reduced basis are short, and near orthogonal. Here we present generalizations, from which with k = 1, and k = n we can recover their inequalities: Theorem 1. Let b1, . . . , bn ∈ R be an LLL-reduced basis of the lattice L, and d1, . . . , dk arbitrary linearly independent vectors in L. Then ‖b1 ‖ ...

Let G be a graph, u be a vertex of G, and B(u)(or BG(u)) be the set of u with all its neighbors in G. A sequence (B1, B2, ..., Bn) of subsets of an n-set S is a neighborhood sequence if there exists a graph G with a vertex set S and a permutation (v1, v2, ..., vn) of S such that B(vi) = Bi for i = 1, 2, ..., n. Define Aut(B1, B2, ..., Bn) as the set {f : f is a permutation of V (G) and (f(B1), ...