The 5-HT7 receptor binding affinities of the oxindole derivatives have been quantitatively analyzed in terms of Dragon descriptors. The derived QSAR models have provided rationales to explain the binding affinity of titled compounds. In order to improve the 5-HT7 receptor binding affinity of a compound higher value of molecular topology and symmetry accounting parameter path/walk 2Randic shape ...

This paper presents new image descriptors based on color, texture, shape, and wavelets for object and scene image classification. First, a new three Dimensional Local Binary Patterns (3D-LBP) descriptor, which produces three new color images, is proposed for encoding both color and texture information of an image. The 3D-LBP images together with the original color image then undergo the Haar wa...

BACKGROUND Quantitative structure-activity relationships (QSAR) analysis of peptides is helpful for designing various types of drugs such as kinase inhibitor or antigen. Capturing various properties of peptides is essential for analyzing two-dimensional QSAR. A descriptor of peptides is an important element for capturing properties. The atom pair holographic (APH) code is designed for the descr...

Based on large-scale data for the yeast Saccharomyces cerevisiae (protein and mRNA abundance, translational status, transcript length), we investigate the relation of transcription, translation, and protein turnover on a genome-wide scale. We elucidate variations between different spatial cell compartments and functional modules by comparing protein-to-mRNA ratios, translational activity, and a...

Local surface description is a critical stage for surface matching. This paper presents a highly distinctive local surface descriptor, namely TriSI. From a keypoint, we first construct a unique and repeatable local reference frame (LRF) using all the points lying on the local surface. We then generate three spin images from the three coordinate axes of the LRF. These spin images are concatenate...

Molecular Field Topology Analysis (MFTA) [1] is a QSAR approach based on the local (atomic) descriptors. First, a so-called molecular supergraph is constructed which is a simple graph such that the molecular graphs of all training set structures can be represented as its subgraphs. A uniform descriptor set for the statistical analysis is obtained by superimposing each training set structure ont...

Musical timbre is a phenomenon of auditory perception that allows the recognition musical sounds. The challenging task because instrument or sound source complex and multifaceted influenced by variety factors, including physical properties source, way it played produced, recording processing techniques used. In this paper, we explore an abstract space with 7 dimensions formed fundamental freque...