OBJECTIVES This study aimed to investigate patients' willingness to initiate a preventive treatment and compared two established effect measures to the newly developed Delay of Events (DoE) measure that expresses treatment effect as a gain in event-free time. METHODS In this cross-sectional, randomized survey experiment in the general Swedish population,1079 respondents (response rate 60.9%) ...

A general method for the N-arylation of amino acid esters with aryl triflates is described. Both α- and β-amino acid esters, including methyl, tert-butyl, and benzyl esters, are viable substrates. Reaction optimization was carried out by design of experiment (DOE) analysis using JMP software. The mild reaction conditions, which use t-BuBrettPhos Pd G3 or G4 precatalyst, result in minimal racemi...

Support vector machines (SVM) is an effective tool for building good credit scoring models. However, the performance of the model depends on its parameters’ setting. In this study, we use direct search method to optimize the SVM-based credit scoring model and compare it with other three parameters optimization methods, such as grid search, method based on design of experiment (DOE) and genetic ...

Optimizing parameter settings is an important task in algorithm design. Several automated parameter tuning procedures/configurators have been proposed in the literature, most of which work effectively when given a good initial range for the parameter values. In the Design of Experiments (DOE), a good initial range is known to lead to an optimum parameter setting. In this paper, we present a fra...

a study to evaluate the reproductive performance of abergelle goat was carried out at sekota district of amhara national regional state. on-farm flocks from two peasant associations were monitored for two years to collect data. data collected included identification number of doe and kid, birth / kidding date, kid birth weight, sex of kid, post partum doe weight, litter size, parity of doe. dat...

Problems in design of technical systems can be solved by optimization or inventive solving principles. Two representation models are studied: Generalized System of Contradictions (GSC) as inventive principle and Design of Experience (DoE) as optimisation principle. Our purpose is to improve the capacity of design problems resolution by using the both solving principles articulated to one repres...

background and objectives: microbial caffeine removal is a green solution for treatment of caffeinated products and agro-industrial effluents. we directed this investigation to optimizing a bio-decaffeination process with growing cultures of pseudomonas pseudoalcaligenes through taguchi methodology which is a structured statistical approach that can be lowered variations in a process through de...

In this work, the laser forming process of cylindrical surfaces is studied experimentally. For purpose, effects parameters such as power, scanning scheme, and distance between irradiation lines on radius curvature laser-formed are examined. The design experiment (DOE) method based Box–Behnken algorithm also employed for investigations. To produce from flat sheets, parallel used scheme. results ...

Advanced high strength steels (AHSS) are multiphase that contain various concentrations of ferrite, bainite, martensite, and retained austenite phases. The unique physical characteristics AHSS present some challenges to welding bonding processes. have tendency change microstructure mechanical properties by any process like other steels. Based on the significant applications in industries, exper...