Desmoplastic malignant melanoma is a rare variant of spindle cell melanoma, commonly seen in older adults, on sun-exposed areas. It accounts for 1-4% of all cases of cutaneous melanoma. The common location of the desmoplastic melanoma is the head and neck region, whereas, other sites are less common. Regional lymph node involvement is reported in 0 to 13.7% of the cases, which is less frequent ...

Abstract Background Desmoplastic changes in a tumor have been observed to affect the microenvironment, leading both facilitation and prevention of invasiveness. Methods Between 2016 2020, total 120 patients were diagnosed with gallbladder carcinoma. The cases reviewed for type desmoplastic reaction, grade, stage. reaction was classified as mature, intermediate, immature, they correlated grade R...

Intraarticular synovial fibroma is extremely rare with only 14 known cases reported in the literatures. Descriptions and illustrations about the imaging features are also limited. We hereby present a case of synovial fibroma in the knee joint which shares similar imaging features and clinical presentations with localized pigmented villonodular synovitis (PVNS). Therefore, it is important that s...

A case of peripheral ossifying fibroma (POF) in the mandibular gingiva of a 30-year-old man is described. The lesion was asymptomatic, firm, pinkish red and pedunculated histologically showing cellular, fibrous connective tissue stroma with calcified osseous and cementum-like calcifications. Lesions histologically similar to peripheral ossifying fibroma (POF) have been given various names in th...

Calcifying aponeurotic fibroma is a rare soft tissue tumor that typically occurs in the distal extremities of children and adolescents. Because a calcifying aponeurotic fibroma is an ill-defined mass and has a tendency to infiltrate the surrounding tissue, local recurrence rates are 50%. We report a case of calcifying aponeurotic fibroma occurring in the elbow region, an uncommon site. The pati...

neous biopsies, yielding 69 collision tumors. Cascajo and colleagues found 54 collision tumors of malignant cutaneous neoplasms associated with seborrheic keratoses in 85,000 biopsies. The most common combinations found by Boyd and Rapini included basal cell carcinoma and nevus (14), basal cell carcinoma and seborrheic keratosis (8), nevus and seborrheic keratosis (14), actinic keratosis and ne...

Trichoepithelioma (TE) is a benign skin neoplasm derived from the hair follicle. It is commonly located on the face and hairy skin. Malignant transformation is quite rare. TE affects adults and more frequently women. The most common presentations are noted in the 4th decade [1]. There are three variants of TE: solitary TE, multiple TE and desmoplastic TE [2-4]. The solitary TE is non-familial. ...

BACKGROUND AND OBJECTIVES Desmoplastic melanoma is a unique subtype of melanoma which typically affects older patients who often have comorbidities that can adversely affect survival. We sought to identify melanoma-specific factors influencing survival in patients with desmoplastic melanoma. METHODS Retrospective review from 1993 to 2011 identified 316 patients with primary desmoplastic melan...

Medulloblastomas (MBs) are primitive neuroectodermal tumors (PNET) of the cerebellum. They represent the most frequent malignant pediatric brain tumors, but their origin still remains unresolved and controversial. MB cells correspond to different stages of neural development and differentiation as illustrated by their expression of neuronal and glial markers. In the present study, we examined t...

The hallmark of pancreatic tumours, the desmoplastic reaction, provides a unique microenvironment that affects pancreatic tumour behaviour, its ability to grow and metastasize as well as resist the effects of chemotherapy. Complex molecular interactions and pathways give rise to the desmoplastic reaction. Breakdown or penetration of the desmoplastic reaction may hold the key to overcoming the l...