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تعداد نتایج: 2792616 فیلتر نتایج به سال:
Understanding the extreme variation among bacterial genomes remains an unsolved challenge in evolutionary biology, despite long-standing debate about the relative importance of natural selection, mutation, and random drift. A potentially important confounding factor is the variation in mutation rates between lineages and over evolutionary history, which has been documented in several species. M...
Introduction: This study was designed to evaluate potential reversibility of left ventricular (LV) dysfunction in patients with acromegaly following long-term control of disease. It is unknown, whether the cardiac changes induced by acromegaly can be completely reversed by long-term strict control of growth hormone (GH) excess by octreotide. Patients and Methods: We compared LV systolic and dia...
CONTEXT Cushing's syndrome (CS) is associated with symptoms that may impair health-related quality of life (HRQL). METHODS We used the short-form 36 survey to evaluate HRQL in 23 patients with Cushing's disease before and after transsphenoidal surgery (age, 42.7 +/- 12.0 yr; 19 women and four men) and in a cross-section of 343 CS patients (age, 48.2 +/- 14.1 yr; 265 women and 78 men) in remis...
Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy carriers, nor whether specific S. aureus types are associated with GPA. Therefore, this study was aimed a...
The aim of our study was to test the robustness and efficiency of maximum likelihood with respect to different long branch effects on multiple-taxon trees. We simulated data of different alignment lengths under two different 11-taxon trees and a broad range of different branch length conditions. The data were analyzed with the true model parameters as well as with estimated and incorrect assump...
INTRODUCTION This study was designed to evaluate potential reversibility of left-ventricular (LV) dysfunction in patients with acromegaly following long-term control of disease. It is unknown whether the cardiac changes induced by acromegaly can be reversed completely by long-term strict control of growth hormone excess by octreotide. PATIENTS AND METHODS We compared LV systolic and diastolic...
Asthma, remains symptomatic despite ongoing treatment with high doses of inhaled corticosteroids (ICS) in conjunction with long-acting beta-agonists (LABA), is classified as "severe" asthma. In the course of caring for those patients diagnosed with severe asthma, stepping up from ICS/LABA to more aggressive therapeutic measures would be justified, though several aspects have to be checked in ad...
BACKGROUND AND AIMS The morphological structure of anthetic carpels of Brasenia (Cabombaceae), a member of the phylogenetically basal ANITA grade, has not been studied before. The carpel has a long stigmatic crest on the ventral side and could give the impression of a conduplicate structure. This is in contrast to the carpel structure in other genera of the ANITA grade. Therefore, a study of ca...
OBJECTIVE Iodine Deficiency (ID) was for years considered a contributing factor for endemic goiter in Iran. The present study was conducted to assess the goiter prevalence and iodine status in schoolchildren of Isfahan 16 years after the initiation of salt iodization in Iran. DESIGN 2331 schoolchildren, aged 6-13 years were selected by multistage random sampling. Thyroid size was estimated in...
OBJECTIVE Weight loss reduces abdominal and intrahepatic fat, thereby improving metabolic and cardiovascular risk. Yet, many patients regain weight after successful diet-induced weight loss. Long-term changes in abdominal and liver fat, along with liver test results and insulin resistance, are not known. RESEARCH DESIGN AND METHODS We analyzed 50 overweight to obese subjects (46 ± 9 years of ...
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