Resveratrol, a phytoalexin present in the skin of grapes and red wine, has been demonstrated to possess a wide range of health promoting activities including anti-diabetic properties. In the present study, we investigated the effect of resveratrol in both type 2 diabetic mice and cell culture systems. In cultured L6 myotubes, we studied the effect of resveratrol on glucose uptake and translocat...

OBJECTIVE Puerarin is a natural flavonoid isolated from the TCM lobed kudzuvine root. This study investigated the effect and mechanisms of puerarin on diabetic aorta in rats. METHODS Streptozotocin- (STZ-) induced diabetic rats were administered with puerarin for 3 weeks. Levels of serum insulin (INS), PGE2, endothelin (ET), glycated hemoglobin (GHb), H2O2, and nitric oxide (NO) in rats were ...

background and objective: due to the presence of some evidence for anti-diabetic and antioxidant activity of tribulus terrestris (tt), this study was designed to investigate the anti-nociceptive effect of tt in streptozotocin-diabetic rats using formalin test and hot tail immersion tests. materials and methods: rats were divided into control, tt-treated control, diabetic, sodium salicylate (ss)...

abstract          background and objective: according to iranian, asian, indian, and chinese traditional medicine, basil is used in the treatment of different diseases. in this study, the effect of basil on lowering the blood glucose was examined in healthy and diabetic rats.         methods: sixty wistar rats were divided into a control group(n=10), a basil receiving group (n=20) and a diabeti...

Experimental diabetes in rodents rapidly affects the neurogenic niches of the adult brain. Moreover, behavioral disorders suggest that a similar dysfunction of the neurogenic niches most likely affects diabetic and prediabetic patients. Here, we review our present knowledge about adult neural stem cells, the methods used for their study in diabetic models, and the effects of experimental diabet...

introduction: some studies show magnesium has anticonvulsive effect in some animal models. despite of the availability of well-studied anticonvulsant drugs, this evaluation was not carried on new kind of magnesium supplement, magnesium oxide nanoparticles (nmgo). according to the interaction between magnesium and convulsion, this study was designed to evaluate the effect of nmgo on strychnine-i...

The relationship between the effect of aldose reductase inhibitors (ARIs) on the activation of the polyol pathway and on diabetic neuropathy has not been fully established. To address this issue, we investigated the effect of epalrestat (150 mg/day), an ARI, on erythrocyte sorbitol levels as an index of polyol activation and on nerve function test results in 43 patients with diabetic peripheral...

background: considering the dramatic increasing rate of diabetes and consequently its related complications, most importantly diabetic peripheral neuropathy (dpn), challenges regarding proper treatment of dpn and its effect on the quality-of-life and care of diabetic patients, the aim of this current study is to evaluate the effect of intradermal botulinum toxin type a (btx-a) injections on pai...