background: acute leukemias are characterized by neoplastic proliferation of hematopoietic stem cells and accumulation of blasts and immature cells in the bone marrow. we applied a selective panel of immunohistochemical markers on bone marrow trephine tissue sections and observed their utility in diagnosis and typing of acute leukemia. materials and methods: the study was done at psg institute ...

Abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. We report an 11 years old girl who developed central hypothyroidism and ACTH deficiency during the chemotherapy for CNS relapse of acute lymphoblastic leukemia before receiving radiotherapy. Keywords: Thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leu...

a 54 year old man with history of cardiomyopathy and chronic fibrillation first presented with bloody diarrhea. then during the assessment of his abnormal lab. data revealed cast nephropathy in renal biopsy, gamma peak in protein electrophoresis and fine lytic lesions in skull graphy. his bone marrow aspiration showed multiple myeloma and blood smear revealed plasma cell leukemia. our patient w...

fab (french – american- british) group determined a diagnostic classification for leukemia's. but in spite of some reports on different clinical findings and prognosis of hmc and lgl there is no place for hand- mirror cell leukemia and lgl leukemia in this classification. on the other hand, there are different ideas about causes of hand mirror cell and about different changes of large granlar l...

purpose: to report a case of acute myelogenous leukemia (aml) presenting with periorbital cellulitis and progressing to facial and neck cellulitis. case report: a 17 year old male patient presented with periorbital cellulitis which progressed to the right hemifacial and neck area. he did not respond to regular antibiotic therapy. peripheral blood smear showed leukocytosis with predominance of i...

Objective: To study whether the generated CD1a positive cells belong to the leukemic cells among patients with juvenile myelomonocytic leukemia. Materials and Methods: We used mononuclear cells from 3 patients with juvenile myelomonocytic leukemia, from which two had monosomy 7. The mononuclear cells from these patients were cultured in RPMI/10%FCS without adding exogeneous growth factors fo...

background: acute lymphoblastic leukemia (all) is the most common form of childhood cancer leading to cancer-related death in children. most infants with all harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of the disease. mixed-lineage leukemia-rearrangement (mll-rearrange...

laparoscopic orchiopexy (lo) was used in place of open surgery in 10 patients for diagnosing cryptorchidism in our department. in this method a large abdominal incision was not given in search of intra-abdominal testes. anorchia was diagnosed in four patients, which was shown to be bilateral in one. in one subject with ambiguous genitalia, revealing the presence of intra-abdominal gonads establ...

chronic lymphocytic leukemia (cll) and chronic myeloid leukemia (cml) are the most common leukemias of the elderly (>43 year). however, the sequential occurrence of cml followed by cll in the same patient is extremely rare. in our report, a 52-year-old female was diagnosed with cll (type of bone marrow (bm) infiltration was nodular and interstitial) and was treated with chlorambucil. 64 months ...

introduction: apoptosis is an important mechanism in both physiological and pathological conditions. the bcl2 family of proteins plays a critical role in regulation of apoptotic cell death. up and down regulation of bcl2-like 12 (bcl2l12), a new member of the bcl2 family, has been reported in several malignancies. however, the expression level of bcl2l12 rarely has been studied in leukemia. thi...