Several methods are available in literature for the determination of percentage purity of diazepam (pharmaceutical raw material) either by non aqueous titration or spectrophotometric methods. For the quantitative determination of diazepam from the commercial pharmaceutical preparations, the current official B.P method (nonaqueous titration and spectrophotometric assay) has been utilized and a c...

Tritiated diazepam accumulates mainly in the mitochondria of the unicellular Tetrahymena. This is the case in both a single (the first encounter) and a repeated (one day or a week after the first) administration of the drug. When imprinting of Tetrahymena by diazepam (the first encounter) is followed a week later by the administration of the labelled drug, the membranes of the vesicles, too, sh...

Introduction: Adjuvant medications can be used to increase the analgesic effect of opioid analgesics, reduce manifestation side effects, and also for premedication. This paper provides information on clonidine, haloperidol, metocloparmide, diazepam, midazolam analgesics: - morphine selective kappa-opioid agonist compound RU-1205.
 Materials methods: A probable interaction between RU-1205, ...

Safety index (S.I.) of ether, chloroform and halothane was determined in mice following premedication with chloral hydrate, phenobarbitone, diazepam and trifluoperazine given alone or in combination with atropine or hyoscine. The S.I. of ether was significantly raised by chloral hydrate and phenobarbitone when combined with atropine while trifluoperazine in combination with atropine or hyoscine...

Midazolam hydrochloride and diazepam in emulsion were compared as i.v. sedatives for spinal anaesthesia. Mean doses of midazolam 12 mg and diazepam 27 mg were required to induce sleep and provide good or adequate sedation throughout surgery of approximately 1 h duration. Neither drug caused loss of the airway or significant cardiorespiratory changes. The frequency of drowsiness after operation ...

The drug midazolam has been recommended to replace diazepam as the immediate anticonvulsant treatment for nerve agent-induced seizures. This recommendation marks the latest decision in an ongoing program to improve medical countermeasures to treat nerve agent poisoning. Extensive rodent screening studies first identified midazolam as the most promising compound to focus on for advanced testing....

The presence of pharmaceutical products in the aquatic environment has been reported in several studies. However, the impact of these drugs on living organisms is still uncharacterized. Here, we investigated the effects of acute exposure to either diazepam or fluoxetine on the stress response in Danio rerio. We showed that diazepam and fluoxetine inhibited the stress axis in zebrafish. Intermed...

Thirty-three patients received either 10 ml (group A) or 50 ml (group B) of water with diazepam tablets as premedication while in the supine position. Plasma diazepam concentrations were measured, a delay in the attainment of the peak plasma concentration being taken as an indication of delayed absorption and oesophageal hold-up. There was no difference between the two groups, although in an im...

Diazepam 1 mg/kg body weight was administered rectally to 14 children (11-22.5 kg) before minor surgery under general anaesthesia. Administration in solution (n = 7) resulted in a rapid increase in serum concentrations which were maintained for 8 h. Administration by suppository (n = 7) resulted in significantly lower serum concentrations at 10 and 20 min, but higher concentrations at 2 h. At o...

Ten subjects received secretin and cholecystokinin or, in duplicate tests, the two hormones together with either diazepam or diazepam plus hyoscine butylbromide in order to determine whether these drugs, which are often used during retrograde endoscopic cannulation of the pancreatic duct, affect pancreatic and biliary secretion in response to the hormones. Diazepam with hyoscine butylbromide re...