This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

Introduction Since the late 1950s and early 60’s, conventional calcium hydrogen phosphate has been widely used as the excipient for direct compression tabletting. However, the fi rst generation of calcium phosphates were hard and rough pillar-like crystals with crystal water, which often caused abrasiveness of punches and dies in tabletting. In addition, the crystal water could possibly be rele...

The crystal structures and hydraulic activities of β and γform dicalcium silicates (β-C2S, γ-C2S) were analyzed by ab-initio calculation based on quantum mechanics. The mean distances less than 4 Å to the neighboring Ca atoms for all of independent Ca atoms were calculated within unit cell. Ca-Ca mean distances are 3.56 Å in β-C2S and 3.75 Å in γ-C2S. The shortening of Ca-Ca distance causes ins...

The bone defect repair functions of calcium phosphate cement (CPC) are related to its osteoconductivity and its gradual replacement by new bone. Adding mannitol to CPC may enhance its bone repair potential by increasing CPCs macroporosity and dissolution rate. The objective of the study was to assess microporosity and macroporosity and dissolution rates for CPC mixed with mannitol. Three groups...

Previous studies reported premixed calcium phosphate cements (CPCs) that were stable in the package and form hydroxyapatite (HA) as the product after exposure to an aqueous environment. These cements had setting times of greater than 60 min, which are too long to be useful for some clinical applications. The present study investigated properties of fast-setting HA-forming premixed CPCs that ini...

Background: Seaweeds are rich in complex carbohydrates, proteins and low molecular weight nitrogenous compounds, lipids, organic minerals, vitamins pigments. The aim of the study was to evaluate effect seaweed formulations on nutrient utilization, growth performance, serum antioxidant activity cell mediated immune response crossbred calves. Methods: Eighteen male calves (130±7.56 kg body weight...

We tested the hypothesis that fate of dietary phosphorus will not differ among a dicalcium phosphate-free practical diet treated with 6-phytase (3000 FTU/kg; Quantum Blue™; P-F + Phy), and positive (C) negative (P-F) control diets when fed to hybrid tilapia (Oreochromis aureus x O. niloticus; 29.8 g initial weight) stocked at 29 fish/m3 grown for 5 months market size (454 g/fish) in outdoor bio...