The relationship between the pharmacokinetics and the antinociceptive effect of diclofenac was evaluated using the pain-induced functional impairment model in the rat. Male Wistar rats were injected with uric acid in the knee joint of the right hind limb, which induced its dysfunction. Once the dysfunction was complete, animals received a p.o. dose of 0.56, 1, 1.8, 3.2, 5.6 or 10 mg/kg of sodiu...

BACKGROUND Topically applied nonsteroidal anti-inflammatory drugs (NSAIDs) are used widely for the treatment of pain and inflammation in musculoskeletal disorders. This study compared the analgesic and anti-inflammatory effects of patches of 1% diclofenac-sodium, 3.5% and 0.5% felbinac and 3.75% indomethacin in rats using the carrageenan-induced paw pad edema model and the brewer's yeast-induce...

Drug-plasma protein binding is one of the many factors which influence bioavailability of a drug. Efficacy, distribution and elimination of a drug can be affected by the reversible binding of the drug to plasma proteins, such as albumin and acid glycoprotein. The purpose of the study was to study the relative in vitro protein binding characteristics of various drugs like diclofenac sodium, pant...