نتایج جستجو برای: diethylnitrosamine

تعداد نتایج: 1220  

2006
Mantu Bhaumik Thomas Harris Subha Sundaram Linda Johnson Joseph Guttenplan Charles Rogler Pamela Stanley

The glycosyltransferase termed GlcNAc-TIII is dedicated to the trans fer of a single W-acetylglucosamine (GlcNAc) residue (the bisecting GlcNAc), to a subset of W-glycans in glycoproteins. The addition of this GlcNAc is differentially regulated during development and is induced in certain cancers, particularly in hepatic tumorigenesis. To investigate a functional role for the bisecting GlcNAc i...

2005
Ee Hong Tan Shing Chuan Hooi Mirtha Laban Esther Wong Sathivel Ponniah Aileen Wee Nai-dy Wang

The CCAAT/enhancer binding protein A (C/EBPA) is vital for establishing normal hepatic energy homeostasis and moderating hepatocellular growth. CEBPA loss-of-function mutations identified in acute myeloid leukemia patients support a tumor suppressor role for C/EBPA. Recent work showed reductions of C/EBPA levels in human hepatocellular carcinoma with the reductions correlating to tumor size and...

Journal: :Hepatology 1996
R V Pearline Y Z Lin K J Shen E M Brunt W M Bowling D G Hafenrichter S Kennedy M W Flye K P Ponder

An understanding of how oncogenes affect differentiated liver functions might lead to improved treatments for liver cancer or other disorders where liver-specific functions are compromised. A retroviral vector that coexpressed beta-galactosidase (beta-gal) and activated Ras genes (Ras-gal) was transduced into a small fraction of adult rat hepatocytes in vivo. Hepatocytes from Ras-gal-transduced...

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