peripheral t-cell lymphomas are a group of heterogeneous disorders and according to who classification, are categorized into nodal and extranodal forms. nk/t-cell lymphoma, nasal type, is a subtype of extranodal peripheral t-cell lymphoma and commonly presents as a midfacial destructive lesion. this disorder is more prevalent in asia and south america and has a strong association with epstein b...

In this issue of Blood, Matasar and colleagues report the results of salvage treatments with anti-CD20 ofatumumab in combination with ifosfamide, carboplatinum, etoposide (ICE) or dexamethasone, high-dose cytarabine, cisplatin (DHAP) in relapsed refractory diffuse large B-cell lymphoma (DLBCL) before transplantation. They conclude that replacing rituximab with ofatumumab in second-line therapy ...

Cutaneous diffuse large B-cell lymphoma accounts for ~6% of all cutaneous lymphomas. It is associated with poor prognosis, and solitary lesions are relatively rare. It often requires an aggressive approach with multi-agent chemotherapy and radiotherapy. It is important to recognize these cases in order to offer rapid and appropriate management.

Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma (NHL) in adults. Even if the natural history of DLBCL has been improved with the advent of immunochemotherapy, the survival results obtained with current treatment options clearly indicate that new agents or novel approaches are needed. Lenalidomide (Revlimid, Celgene Corporation, Summit, NJ, USA), an analog...

BACKGROUND The optimal treatment of primary gastric large-cell non-Hodgkin's lymphoma (PGL) has not been defined. Recent studies have suggested that organ-preserving treatment produces the same results as surgical treatment. METHODS We retrospectively reviewed the data of 88 patients diagnosed with PGL between 1995 and 2003 at Chang Gung Memorial Hospital. Sixty-two patients received chemothe...

B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymph...

Activation of the phosphatidylinositol 3-kinase/mechanistic target of rapamycin pathway plays a role in the pathogenesis of non-Hodgkin lymphoma. This multicenter, open-label phase 2 study evaluated buparlisib (BKM120), a pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or refractory non-Hodgkin lymphoma. Three separate cohorts of patients (with diffuse large B-cel...

The incidence rate of Primary cardiac lymphoma is very low. Primary cardiac lymphoma within myxoma is extremely rare disease. So far, these cases have been reported only eight in the world, which has not reported in Chinese so far. Hence, we reported the unique Chinese case of 52-year-old immunocompetent male with primary Epstein-Barr virus positive diffuse large B-cell lymphoma arising within ...