Brain extracellular space (ECS) is an interconnected channel that allows diffusion-mediated transport of signaling molecules, metabolites, and drugs. We tested the hypothesis that β-adrenergic receptor (βAR) activation impacts extracellular diffusion-mediated transport of molecules through alterations in the morphology of astrocytes. Two structural parameters of ECS-volume fraction and tortuosi...

OBJECTIVE To investigate the effects of chemotherapy and cranial irradiation on normal brain tissue using in vivo neuroimaging in patients with glioblastoma. METHODS We used longitudinal MRI to monitor structural brain changes during standard treatment in patients newly diagnosed with glioblastoma. We assessed volumetric and diffusion tensor imaging measures in 14 patients receiving 6 weeks o...

Aerosol fire extinguishing agents have been recognized as an effective replacement of Halon. The uniform diffusion time and the effective concentration of the aerosol fire extinguishing agent are important parameters for putting out a fire. In this work, the effective concentration is derived based on the diffusion equation, and its variation with changing diffusion coefficient and diffusion ti...

A three-dimensional computational fluid dynamics model of a proton exchange membrane fuel cell (PEMFC) with both gas distribution flow channels and Membrane Electrode Assembly (MEA) is developed. A set of conservation equation is numerically solved by developing a CFD code based on the finite volume technique and SIMPLE algorithm. In this research, some parameters like oxygen consumption, water...

The dependence of viscosity behavior on volume loadings of well dispersed Alumina – polyvinyl butyral (Al-PVB) tape casting slurry by varying particle sizes has been studied at constant shear rate 4 sec with the help of a conventional couette device. The slurry under constant shear rate showed an interesting behavior of suspensions with time and volume change by varying the particle size. From ...

A nonlinear discrete duality finite volume scheme is proposed for time-dependent diffusion equations. The model example written in a new formulation giving rise to similar nonlinearities both the and potential functions. natural discretization built on this particular problem's structure. fluxes are generically approximated thanks key fractional average. point of strategy promote coercivity sch...

Diffusion tensor microimaging with 40 μm isotropic voxels at 16.4 T was used to investigate compartmentation of water diffusion and biexponential diffusion decay in formalin fixed prostate tissue. Tissue samples (~28 mm) were similar in volume to a typical prostate DWI voxel in vivo and were imaged with ~400,000 voxels. The bulk mean diffusivity (‘ADC’) of epithelial, stromal, and ductal/acinal...