We present a new technique for acquiring and analyzing intrinsic signal optical images of brain activity, using continuous stimulus presentation and data acquisition. The main idea is to present a temporally periodic stimulus and to analyze the component of the response at the stimulus frequency. Advantages of the new technique include the removal of heart, respiration, and vasomotor artifacts,...

Tissue clearing methods promise to provide exquisite three-dimensional imaging information; however, there is a need for simplified methods for lower resource settings and for non-fluorescence based phenotyping to enable light microscopic imaging modalities. Here we describe the simplified CLARITY method (SCM) for tissue clearing that preserves epitopes of interest. We imaged the resulting tiss...

The radiographic image is the bidimensional projection of a tridimensional volume. Interpretation of such an image is sometimes uneasy as we cannot determine ot which level the shadows are located. To dissociate the superimposed shadows, the radiologist may rely on different techniques including fluoroscopy, profile view, radiosteoroscopy, conventional tomography, transverse axial tomography or...

INSERM U 895, University Nice Sophia Antipolis, 151 route Saint-Antoine de Ginestière, BP 2 3194, 06204 Nice cedex 3, France. UMR S775, University Paris Descartes, 45 rue des Saints Pères, 75006, Paris, France. 3 C.N.R.S., Unité de Neurosciences Information et Complexité, 91198 Gif-sur-Yvette, France § Present address: Zerial Laboratory, Max Planck Institute of Molecular Cell Biology and Geneti...

The complex anatomy of mitral valve demands precise and sophisticated imaging during any intervention .Transesophageal echocardiography has been the most frequently used modality. With the advent of three-dimensional echocardiography a more comprehensive description of the mitral valve is now possible. This review aims to discuss the framework for imaging the mitral valve by three-dimensional e...

Analysis of array data from acoustic scattering in a random medium with a small number of isolated targets is performed in order to image and, thereby, localize the spatial position of each target. Because the host medium has random fluctuations in wave speed, the background medium is itself a source of scattered energy. It is assumed, however, that the targets are sufficiently larger and/or mo...

Extracting neuronal spiking activity from large-scale two-photon recordings remains challenging, especially in mammals in vivo, where large noises often contaminate the signals. We propose a method, MLspike, which returns the most likely spike train underlying the measured calcium fluorescence. It relies on a physiological model including baseline fluctuations and distinct nonlinearities for sy...

The HEGRA system of Imaging Atmospheric Cherenkov Telescopes (IACTs) detects Cherenkov light produced by air showers. The concept of stereoscopic observation with the five HEGRA telescopes allows the reconstruction of various shower parameters, for example the shower direction, the location of the shower core and the energy of cosmic rays. One of the telescopes was modified so that measurements...

We report a new approach to preparing phantoms using 3D printing. This device supports plastic tubing containing the contrast agent and is immersed in a solution with absorption or scattering properties that mimic tissue. Up to 12 tubing samples could be placed in the device with sample-to-sample spacing as low as 0.3 mm and at a constant distance from the transducer (±0.16 mm), which is critic...

The popularity of hyperspectral imaging (HSI) in remote sensing continues to lead to it being adapted in novel ways to overcome challenging imaging problems. This paper reports on research efforts exploring the phenomenology of using HSI as an aid in detecting and tracking human pedestrians. An assessment of the likelihood of distinguishing between pedestrians based on the measured spectral ref...