Enantioselective resolution of a racemate cis-3 is performed by Candida antarctica lipase B. The hydrolyzed product in its (2R,3S) can be used for the preparation neuromediator analogue, while non-reacted (2S,3R) substrate building block antibiotic Moxifloxacin. enzyme shows both enantioselectivity as well regioselectivity ester position 3.

Biphenyl Dimethyl Dicarboxylate (DDB) and Silymarin are widely used drugs for the treatment of hepatitis C virus, have poor bioavailability due to their low aqueous solubility that limits their dissolution rates. To overcome these limitations solid dispersions (SDs) and self-microemulsifing drug delivery systems (SMEDDS) were prepared in an attempt to improve their release profile. SDs were pre...

Two zinc(II) complexes with dimethyl 2,2′-bipyridine-4,5-dicarboxylate (py-2py) of the general formula [Zn(py-2py)X2], X = Cl− (1) and Br− (2) were synthesized characterized by NMR, IR UV-Vis spectroscopy single-crystal X-ray diffraction analysis. Complexes 1 2 are isostructural adopt a slightly distorted tetrahedral geometry values indices τ4 τ’4 in range 0.80–0.85. The evaluated for their vit...