We show that vimentin filaments are present in undifferentiated Friend murine erythroleukemia cells, but are lost progressively to undetectable levels by 96 h of dimethyl sulfoxide-mediated differentiation. The amount of newly synthesized cytoskeletal vimentin is decreased dramatically by 24 h of induction, and is paralleled by a rapid loss of vimentin mRNA (approximately 25-fold reduction at 9...

The 25-35 fragment of the amyloid β(Aβ) peptide is a naturally occurring proteolytic by-product of its larger parent molecule that retains the amyloid characteristics and toxicity of the full length parent molecule. Aggregation of this peptide occurs rapidly in aqueous solutions and thus characterization of its folding process is very difficult. In the present study, early stages of Aβ(25-35) f...

In the title compound, [CdI(2)(C(12)H(12)N(2))(C(2)H(6)OS)], the Cd(II) cation is coordinated by two N atoms from a dimethyl-bipyridine ligand, one O atom from a dimethyl sulfoxide mol-ecule and two I(-) anions in a distorted trigonal-bipyramidal geometry. Intra-molecular C-H⋯O hydrogen bonding and inter-molecular π-π stacking between parallel pyridine rings [centroid-centroid distance = 3.658 ...

In the mol-ecule of the title compound, [CdBr2(C14H12N2)(C2H6OS)], the Cd(II) atom is five-coordinated in a distorted trigonal-bipyramidal configuration by two N atoms from a 2,9-dimethyl-1,10-phenanthroline ligand, one O atom from a dimethyl sulfoxide ligand and two Br atoms. In the crystal, π-π contacts between the pyridine and benzene rings [centroid-centroid distances = 3.710 (5), 3.711 (6)...

SUMMARY Dimethyl sulfoxide is a convenient solvent of 7,12-dimethylbenz(a)anthracene and related polycycic aromatic hydrocarbons for i.v. injection. As judged by its ability to induce both adrenal necrosis and mammary tumors, this solu tion is at least as active as fatty emulsions of 7,12-dimethyl benz(a)anthracene now in general use. While the preparation of emulsions is timeconsuming andrequi...

density functional (dft) calculations at m05-2x/aug-cc-pvdz level were used to analyze the interactions between dimethyl sulfoxide (dmso) dimers. the structures obtained have been analyzed with the atoms in molecules (aims) and natural bond orbital (nbo) methodologies. four minima were located on the potential energy surface of the dimers. three types of interactions are observed, ch•••o, ch•••...

Proteins absorbed directly onto nitrocellulose membranes were stained with amido black, ponceau S, colloidal silver, or Coomassie blue and solubilized in dimethyl sulfoxide and the absorbance was measured spectrophotometrically. The optimal wavelength of each dye/protein/nitrocellulose solution was found to be at 625, 529, 420, and 600 nm, respectively. A linear relationship was found between t...

In the title complex, [Pt(C(6)H(4)NO(2))Cl(C(2)H(6)OS)], the Pt(II) ion is in a distorted square-planar environment defined by the N and O atoms from the chelating pyridine-2-carboxyl-ate (pic) anionic ligand, one S atom of the dimethyl sulfoxide mol-ecule and one Cl ion. The complex is disposed about a crystallographic mirror plane parallel to the ac plane passing through all the atoms of the ...