Addition of anions derived from dialkyl methylphosphonates to (Ss)-N-tert-butanesulfinyl (3,3,3)-trifluoroacetaldimine afforded (Ss,R) addition adducts in moderate to good yield (53-75%) with excellent diastereoselectivity (94-95% de). After selective removal of the N-sulfinyl group, dipeptides containing enantiomerically pure diethyl 2-amino-3,3,3-trifluoropropylphosphonate were synthesized to...

Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.

Mixed monolayer protected gold nanoparticles were prepared featuring functional groups on their surfaces that can engage in interactions with peptides. DOSY NMR binding studies indicate that nanoparticles containing a combination of three orthogonal functional groups are more efficient in binding to dipeptides than mono or difunctionalised analogues.

In this study, a series of dipeptide compounds were synthesized as result the reaction Fmoc group-protected amino acids and chalcones with triazine reagent. The structures characterized by FT-IR, 1H 13C APT NMR spectroscopy techniques. electrical behavior conjugares was investigated an impedance analyzer in frequency range 1-30 kHz. variation dielectric constant, loss, susceptibility parameters...