OBJECTIVES To detect and localize MRI signal changes prior to the parenchymal contrast enhancement that classically defines the radiologic onset of the developing white matter lesion in multiple sclerosis (MS). METHODS We reviewed 308 high-resolution (≤1 mm(3) voxels) MRI scans at 3T and 7T in 29 patients with active MS. The presence of pre-parenchymal enhancement abnormalities before the app...

Network management (NM) is essential to the safety and reliability of in-vehicle communication networks. This paper reports on a software development of OSEK/VDX direct NM specified in ISO 17356-5. The design flow, consisting of software implementation, manually functional verification and auto-testing, is elaborated step by step. Following this design flow, the NM software development is strai...

The ability to catalyse an electrode reaction via direct (mediatorless) electron transfer has been demonstrated for a number of redox enzymes. In the case of mediatorless electron transfer, the electron is transferred directly from the electrode to the substrate molecule via the active site of the enzyme, or vice versa. The electron itself is the second substrate for the reaction. An important ...

Direct optimization pertains to the use of a single traffic model both for signal timing generation and for plan evaluation. Criteria for model selection include realistic traffic representation, adequate breadth to incorporate most urban traffic management features, and the ability to represent system variability. In the U.S., the CORSIM model is the closest model meeting these requirements. A...

A new thin film heat flux array (HFA) was designed and constructed using a series of nickel/copper thermocouples deposited onto a thin Kapton® polyimide film. The HFA is capable of withstanding temperatures up to 300°C and produces signals of 40 μV/(W/cm). As a result of its thin film construction, the HFA is able to resolve heat flux signals as fast as 32 ms. Calibrations were completed to det...

The gynoecium is the most complex floral organ, designed to protect the ovules and ensure their fertilization. Correct patterning and tissue specification in the developing gynoecium involves the concerted action of a host of genetic factors. In addition, apical-basal patterning into different domains, stigma and style, ovary and gynophore, appears to depend on the establishment and maintenance...

This article describes the synthesis of a pure cortisol-3-(O-carboxymethyl) oxime with its subsequent use in producing highly specific antibodies and a 125I-tracer with a shelf life in excess of several weeks. An assay was developed using a pH of 4, thus allowing a direct measurement of cortisol in serum without extraction or heat denaturation. The quality-control parameters were checked - the ...

PALMER, JEREMY ANDREW. Development of Millimeter Scale Motors For Miniature Direct Drive Robots. (Under the direction of Dr. Edward Grant, and Dr. Jeffrey W. Eischen) The twentieth century marked a period of rapid expansion of technology associated with miniaturization of engineering systems. A recent theme in this trend is the development of miniature, distributed robots that mimic insect beha...

This paper presents an overview of the DIME environment (DIrect Manipulation Environment) being developed by the author. The paper presents the DIME vision, its catalogue of evolutionary transformations—program transformations used by programmers during software maintenance—and scenarios of how they may be used by a programmer during software maintenance. The DIME system will provide for progra...