Recent work has shown that much of the missing heritability of complex traits can be resolved by estimates of heritability explained by all genotyped SNPs. However, it is currently unknown how much heritability is missing due to poor tagging or additional causal variants at known GWAS loci. Here, we use variance components to quantify the heritability explained by all SNPs at known GWAS loci in...

Pelvic measurements, cow weights and cow ages were obtained on 703 Angus- and Hereford-sired cows from five Louisiana Agricultural Experiment Station herds. Cows were either purebred or crossbred, ranging in age from 1 to 14 yr, and sired by 52 Angus and 63 Hereford bulls. All pelvic measurements were obtained via the rectum by the same technician. Paternal half-sib heritability estimates and g...

Heritability estimates for corneal power were found to be high and similar for two populations which differed in their incidence of esotropia. This similarity suggest (1) that genetic differences for corneal power do not contribute to the difference in heritability for spherical refractive error reported for these populations and (2) that this character is not a critical variable contributing t...

Quantitative trait loci (QTLs) underlying multifactorial disorders explain little of the heritability - most is 'missing'. A new yeast study has identified QTLs which explain most heritability in traits. Why is heritability missing in human diseases but not here?

OBJECTIVES Pulse pressure (PP) is a measure of large artery stiffness and has been shown to be an important predictor of cardiovascular morbidity and mortality. The aims of the present study were to investigate the heritability of PP in three studies, the Diabetes Heart Study (DHS), the Insulin Resistance Atherosclerosis Family Study (IRAS FS), and the NHLBI Family Heart Study (FHS), to estimat...

(co) variance components and genetic parameters for growth traits in arman sheep were estimated, using data collected during an 11-year period (1999-2010), by applying the restricted maximum likelihood (reml) procedure under univariate and bivariate animal models. the studied traits were body weight of lamb at birth (bw), body weight at 3 months of age as weaning weight (ww), body weight at 6 m...

SUHMARY Genetic and evironmental variability in gestation length (GL), birth date (BD), and time from first day of breeding season to first observed estrus (FE) were analyzed ·using twelve years of breeding and calving records on cows, sired by Simmental, Maine-Anjou, Limous,in and Gelbvieh bulls. All cows were artificially inseminated. Statistical analyses were performed separately on first, s...

Data obtained during 4 generations of divergent selection for placental efficiency were used to determine factors influencing survival at farrowing and weaning in litters produced by first-parity females. Data were collected from 193 litters and included records on 2,053 individuals. Farrowing survival (FS) and weaning survival (WS) were considered traits of the piglet and were scored 1 if the ...

Since Tysk et al's pioneering analysis of the Swedish twin registry, twin and family studies continue to support a strong genetic basis of the inflammatory bowel diseases. The coefficient of heritability for siblings of inflammatory bowel disease probands is 25 to 42 for Crohn's disease and 4 to 15 for ulcerative colitis. Heritability estimates for Crohn's disease and ulcerative colitis from po...

Beefmaster, Brahman, Brangus, and Santa Gertrudis field data records were used to determine genetic and environmental parameter estimates using a multiple-trait, pseudo-expectation approach. Adjusted birth weight, 205-d weight, and postweaning gain records were analyzed for each breed. Also, Brangus weaning sheath and navel scores were both analyzed using a single-trait, pseudo-expectation meth...