A 57-year-old man with rheumatoid arthritis developed severe anemia during treatment with adalimumab plus methotrexate. Cold agglutinin disease was diagnosed because haptoglobin was undetectable, cold agglutinin was positive (1 : 2048), and the direct Coombs test was positive (only to complement). Although the cold agglutinin titer was normalized (1 : 64) after treatment with prednisolone (0.7 ...

Highly structured nursery habitats promote the survival of juvenile stages of many species by providing foraging opportunities and refuge from predators. Through integrated laboratory and field experiments, we demonstrate that nursery habitat structure affects survival and predator-prey interactions of red king crab Paralithodes camtschaticus. Crabs (<1 yr old [Age 0]; 8 to 10 mm carapace lengt...

The differential sensitivities to permanganate oxidation of the red and far-red forms of native phytochrome from Avena sativa L. cv Mulaga (isolated as Pfr from red-irradiated tissue) and of partially degraded phytochrome (isolated as Pr from nonirradiated tissue) were determined. The far-red absorbing form of partially degraded phytochrome was 5 times more sensitive than its red-absorbing form...

Lipide extracts of the red cells of several animal species have been analyzed chromatographically. Genetically determined differences in phospholipide composition were found. Lecithin is absent from the cells of ox, sheep, and goat. Cells containing lecithin are susceptible to the direct hemolysin of cobra venom while cells not containing lecithin are resistant. The facts indicate that the dire...

Photochemical interconversion between the red-absorbing (P(r)) and the far-red-absorbing (P(fr)) forms of the photosensory protein phytochrome initiates signal transduction in bacteria and higher plants. The P(r)-to-P(fr) transition commences with a rapid Z-to-E photoisomerization at the C(15)=C(16) methine bridge of the bilin prosthetic group. Here, we use femtosecond stimulated Raman spectros...

A simple procedure for determination of trans-resveratrol in wines from Alentejo region delimited appellation (Portugal) is described and validated. A set of 47 red and 21 white wines was analysed by direct injection in high performance liquid chromatograph with UV detector. A detection limit of 0.06 mg/L was achieved. Global uncertainty associated with the results, according to EURACHEM/CITAC ...

This edition of the Journal starts with the big questions in psychiatry: what is a diagnosis? And how does one justify treatment against the will of the individual? The next version of the World Health Organization’s bible, the ICD–11, is being prepared at the same time as the American Psychiatric Association’s fifth edition of the DSM. The push for harmonising these two different systems is di...