نتایج جستجو برای: discover

تعداد نتایج: 35600  

Journal: :Cognitive science 2015
Sanjay Chandrasekharan Nancy J. Nersessian

Novel computational representations, such as simulation models of complex systems and video games for scientific discovery (Foldit, EteRNA etc.), are dramatically changing the way discoveries emerge in science and engineering. The cognitive roles played by such computational representations in discovery are not well understood. We present a theoretical analysis of the cognitive roles such repre...

2016
Peiyong Xin Jijun Yan Bingbing Li Shuang Fang Jinshi Fan Hailong Tian Yong Shi Weisheng Tian Cunyu Yan Jinfang Chu

The exploration and identification of new brassinosteroid (BR) compounds is critical to improve the biosynthetic research of BRs and expand the chemodiversity of active BRs. However, traditional methods are labor-intensive, time-consuming, and less sensitive. Here, we present a facile screening strategy for discovering and identifying novel BRs from plant tissues based on ultra-performance liqu...

2014
Simon D. Fisher Jason P. Gray Melony J. Black Jennifer R. Davies Jeffery G. Bednark Peter Redgrave Elizabeth A. Franz Wickliffe C. Abraham John N. J. Reynolds

Action discovery and selection are critical cognitive processes that are understudied at the cellular and systems neuroscience levels. Presented here is a new rodent joystick task suitable to test these processes due to the range of action possibilities that can be learnt while performing the task. Rats learned to manipulate a joystick while progressing through task milestones that required inc...

2012
Kate Brody Nooner Stanley J. Colcombe Russell H. Tobe Maarten Mennes Melissa M. Benedict Alexis L. Moreno Laura J. Panek Shaquanna Brown Stephen T. Zavitz Qingyang Li Sharad Sikka David Gutman Saroja Bangaru Rochelle Tziona Schlachter Stephanie M. Kamiel Ayesha R. Anwar Caitlin M. Hinz Michelle S. Kaplan Anna B. Rachlin Samantha Adelsberg Brian Cheung Ranjit Khanuja Chaogan Yan Cameron C. Craddock Vincent Calhoun William Courtney Margaret King Dylan Wood Christine L. Cox A. M. Clare Kelly Adriana Di Martino Eva Petkova Philip T. Reiss Nancy Duan Dawn Thomsen Bharat Biswal Barbara Coffey Matthew J. Hoptman Daniel C. Javitt Nunzio Pomara John J. Sidtis Harold S. Koplewicz Francisco Xavier Castellanos Bennett L. Leventhal Michael P. Milham

The National Institute of Mental Health strategic plan for advancing psychiatric neuroscience calls for an acceleration of discovery and the delineation of developmental trajectories for risk and resilience across the lifespan. To attain these objectives, sufficiently powered datasets with broad and deep phenotypic characterization, state-of-the-art neuroimaging, and genetic samples must be gen...

Journal: :Advances in experimental medicine and biology 2015
Alvaro Mordente Elisabetta Meucci Giuseppe Ettore Martorana Andrea Silvestrini

Cancer is one of the major public health problems worldwide representing the leading cause of morbidity and mortality in industrialized countries. To reduce cancer morbidity and mortality as well as to facilitate the evolution from the traditional "one size fits all" strategy to a new "personalized" cancer therapy (i.e., the right drug to the right patient at the right time, using the right dos...

2017
Zhihong O’Brien Mehran F. Moghaddam

BACKGROUND During lead identification and optimization, the advancement criteria may be driven based on scientific principles, prior experiences, and/or by examining the path paved by approved drugs. However, accessing the discovery data on physicochemical and ADME properties of the approved kinase inhibitors is a monumental task as these are either scattered in the literature or have not been ...

Journal: :Expert Opinion on Drug Discovery 2019

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