Cannabinoids represent a promising class of compounds for developing novel therapeutic agents. Since the isolation and identification of the major psychoactive component Δ(9)-THC in Cannabis sativa in the 1960s, numerous analogues of the classical plant cannabinoids have been synthesized and tested for their biological activity. These compounds primarily target the cannabinoid receptors 1 (CB1)...

The primary challenge of grid computing is to enable, maintain, and control the sharing of distributed heterogeneous resources to achieve a common goal. To address this challenge, grid applications should be structured to accommodate the heterogeneous nature of the grid. This project presents a software tool that provides basic services for handling components in the grid domain. The basic oper...

Research Summary Extending the opportunity-discovery perspective on Kirznerian entrepreneurship, we propose a general framework in which new businesses emerge from three distinct mechanisms situated at individual-opportunity nexus: discovery, discernment, and exploitation. We observing opportunities market exchanges characterizing their profitability potential based component that is common to ...

Distributed Drug Discovery (D(3)) proposes solving large drug discovery problems by breaking them into smaller units for processing at multiple sites. A key component of the synthetic and computational stages of D(3) is the global rehearsal of prospective reagents and their subsequent use in the creation of virtual catalogs of molecules accessible by simple, inexpensive combinatorial chemistry....

Parkinson's disease (PD) is a neurodegenerative disorder that markedly affects voluntary action. While regular dopamine treatment can help restore motor function, dopamine also influences cognitive portions of the action system. Previous studies have demonstrated that dopamine medication boosts action-effect associations, which are crucial for the discovery of new voluntary actions. In the pres...

Recent disasters, such as the 2010 Haiti earthquake, have drawn attention to the potential role of citizens as active information producers. By using location-aware devices such as smartphones to collect geographic information in the form of geo-tagged text, photos, or videos, and sharing this information through online social media, such as Twitter, citizens create Volunteered Geographic Infor...

We present a threefold contribution to the computational task of motif discovery, a key component in the effort of delineating the regulatory map of a genome: (1) We constructed a comprehensive large-scale, publicly-available compendium of transcription factor and microRNA target gene sets derived from diverse high-throughput experiments in several metazoans. We used the compendium as a benchma...

To date, research on web-service discovery has followed the tradition of signature matching based on the interface description captured in WSDL. WSDL specifications, however, can be information poor, with basic data types, and unintuitive identifiers for data, messages and operations. The nature of the usage of the WSDL component in the context of a BPEL composition can be an extremely useful s...

Relevance feedback has been an indispensable component for multimedia retrieval systems. In this paper, we present an adaptive pattern discovery method, which addresses relevance feedback by interactively discovering meaningful patterns of relevant objects. To facilitate pattern discovery, we first present a dynamic feature extraction method, which aims to alleviate the curse of dimensionality ...