Nowadays, different types of unexpected turbulence and disruptions lead to challenges changing conditions the environment that organisations operate. The previous studies related crisis response or service recovery have addressed many aspects governance an organisation in reacting failure situations, including innovation bureaucracy, science politics, decision-making speed. However, there is st...

This paper develops and analyzes a simplified model of the dynamics of delay propagation in air traffic networks. The proposed model considers the redistribution of delays by accounting for aircraft flows between airports, the persistence of delays at an airport, the mitigation of delays due to slacks or buffers in flight schedules, and inputs such as sudden impulsive disruptions or sustained i...

We consider the single machine scheduling problem with dynamic job arrival and total weighted tardiness and makespan as objective functions. The machine is subject to disruptions related to late raw material arrival and machine breakdowns. We propose a proactive-reactive approach to deal with possible perturbations. In the proactive phase, instead of providing only one schedule to the decision ...

A crew scheduling algorithms widely used in practice assume no disruptions. Because disruptions often occur, the actual cost of the resulting crew schedules is often greater. We consider algorithms for finding crew schedules that perform well in practice. The deterministic crew scheduling model is an approximation of crew scheduling under uncertainty with the assumption that all pairings will o...

A hot research topic in Genome Science is to analyze the interactions between genes by systematic gene disruptions and gene overexpressions. This paper analyzes the problem of identifying a gene regulatory network from data obtained by multiple gene disruptions and overexpressions in regard to the number of experiments and the complexity of experiments. An experiment consists of a parallel gene...

DNA bending and torsional deformations that often occur during its functioning inside the cell can cause local disruptions of the regular helical structure. The disruptions created by negative torsional stress have been studied in detail, but those caused by bending stress have only been analyzed theoretically. By probing the structure of very small DNA circles, we determined that bending stres...

In this paper, we develop a supply chain/logistics network model for critical needs in the case of disruptions. The objective is to minimize the total network costs, which are generalized costs that may include the monetary, risk, time, and social costs. The model assumes that disruptions may have an impact on both the network link capacities as well as on the product demands. Two different cas...

In recent years, the U.S. health care system has been plagued by shortages of generic sterile injectable drugs. The shortage problem arose suddenly within a short period of time, and remained persistent afterwards. To gain insights into what may have led to this situation, we develop a model that incorporates key characteristics of the generic drug manufacturing industry, including random suppl...

In today’s business environment, harsher and more frequent natural and man-made disasters make supply chains more vulnerable. Supply chain disruptions now seem to occur more frequently and with more serious consequences. During and after supply chain disruptions, companies may lose revenue and incur high recovery costs. If supply chain managers were more capable of measuring and managing supply...

Good resource scheduling plays a pivotal role in successful software development projects. However, effective resource scheduling is complicated by such disruptions as requirements changes, urgent bug fixing, incorrect or unexpected process execution, and staff turnover. Such disruptions demand immediate attention, but can also impact the stability of other ongoing projects. Dynamic resource re...