In April 2013, ten cases of dengue fever in travellers returning from Luanda, Angola, to five countries on four continents, were reported to the globally distributed GeoSentinel Surveillance network. Dengue virus serotype 1 was identified in two cases. The findings indicate that a major dengue outbreak is currently ongoing in Luanda. This report illustrates how cases from an emerging arboviral ...

the Management of Dependences between Activities Sylvain Lizotte & Brahim Chaib-draa Computer Science Department, Laval University, Ste-Foy, PQ, Canada, G1K 7P4 e-mail: {lizotte,chaib}@ift.ulaval.ca Short form of the title: Coordination = Management of Dependences Author to whom correspondence should be sent: B. Chaib-draa Mailing address: Département Informatique, Pav. Pouliot, Université Lava...

SPONTANEOUS BRAIN HEMORRHAGE accounts for about 10% of all strokes and is associated with a high morbidity and mortality rate." While the incidence of stroke due to occlusive cerebrovascular disease has declined the incidence of intracerebral hemorrhage has remained relatively stable. The syndromes that result from brain hemorrhage are sufficiently characterized to permit their clinical recogni...

Treatment for prion disease: recent progress

c 2017 The Korean Society of Neurogastroenterology and Motility J Neurogastroenterol Motil, Vol. 23 No. 4 October, 2017 www.jnmjournal.org TO THE EDITOR: We read with interest the article entitled “Is Gastroesophageal Reflux Disease and Achalasia Coincident or Not” published in January 2017, by Jung and Park. The title raises a very interesting question, however, in the end, the question remain...

Despite a long history of knowing the genetic cause of sickle cell disease (SCD), progress in developing treatments to prevent painful vaso-occlusive crises and the other myriad of associated symptoms has, until recently, been disappointingly slow. As long ago as 1949, Pauling et al described sickle cell anemia as a molecular disease, with two other groups convincingly describing it as an inher...

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255 PRF deficiency occurs not only with allelic variants characterized by mutations in the coding region of the gene. McIlroy et al. reported that the occurrence of a C/T polymorphism at position-398 of the proximal promoter region of the PRF1 gene was associated with decreased quantities of PRF in CTLs in HIV infected patients. A decrease of about 50% of control PRF levels was observed in hete...

Alzheimer's disease, the most common cause of dementia, is characterized by two major pathological hallmarks: amyloid plaques and neurofibrillary tangles. Based on these two indicators, an amyloid cascade hypothesis was proposed, and accordingly, most current therapeutic approaches are now focused on the removal of β-amyloid peptides (Aβ from the brain. Additionally, strategies for blocking tau...

Parkinson's disease (PD) is a chronic, progressive disease of the central nervous system (CNS), characterized by a slow loss of dopaminergic neurons in the substantia nigra, leading to significant decrease in dopamine (DA) levels in the striatum. Currently used drugs, such as levodopa (L-DOPA), amantadine, dopamine agonists (D) or anticholinergic drugs, are not effective enough, and do not elim...