Thermodynamic stability of statistical systems requires that susceptibilities be semipositive and finite. Susceptibilities are known to be related to the fluctuations of extensive observable quantities. This relation becomes nontrivial, when the operator of an observable quantity is represented as a sum of operators corresponding to the extensive system parts. The association of the dispersions...

Rigid-limit 250-GHz electron spin resonance (FIR-ESR) spectra have been studied for a series of phosphatidylcholine spin labels (n-PC, where n = 5, 7, 10, 12, 16) in pure lipid dispersions of dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC), as well as dispersions of DPPC containing the peptide gramicidin A (GA) in a 1:1 molar ratio. The enhanced g-tensor...

The aim of the present work was to improve the solubility and dissolution rate of simvastatin (SIM), a drug used for the treatment of hyperlipidemia. Two systems were used: solid dispersions with PEG 4000 and PEG 6000 prepared using the fusion method in various ratio of 1:1, 1:3, and 1:5 and inclusion complexes with HP-β-cyclodextrin obtained by kneading method in a ratio of 1:1 with drug SIM. ...

The aim of the study was to investigate the physical stability of the semi-solid dispersions into the hard gelatine capsules prepared with Gelucire 44/14, Labrasol and different additives such as microcrystalline cellulose (MCC), mannitol and lactose (alpha-monohydrate) used for enhancing the stability of the formulations. The master dispersion prepared with only Gelucire 44/14 (20% w/w) and La...