We propose Path Disruption Games (PDGs), which consider collaboration between agents attempting stop an adversary from travelling from a source node to a target node in a graph. PDGs can model physical or network security domains. The coalition attempts to stop the adversary by placing checkpoints in intermediate nodes in the graph, to make sure the adversary cannot travel through them. Thus, t...

'Global warming' may be a familiar term, but it is seriously misleading. Human actions are causing a massive disruption to the planet's climate that is severe, rapid, very variable over space and time, and highly complex. The biosphere itself is complex and its responses to even simple changes are difficult to predict in detail. One can likely only be certain that many changes will be unexpecte...

Mine Countermeasures Missions (MCM) take place in very complex and uncertain environments which poses complexity for planning and explanation algorithms. In order to keep a mission on target, constant disruption monitoring and frequent schedule adjustments are needed. To address this capability gap, we have developed the Case-Based Disruption Monitoring and Analyzing (CDMA) algorithm. The CDMA ...

The fatty aldehyde dehydrogenase (FALDH) ALDH3A2 is the causative gene of Sjögren-Larrson syndrome (SLS). To date, the molecular mechanism underlying the symptoms characterizing SLS has been poorly understood. Using Aldh3a2 mice, we here found that Aldh3a2 was the major FALDH active in undifferentiated keratinocytes. Long-chain base metabolism was greatly impaired in Aldh3a2 keratinocytes. Phen...

Protein complexes are a cornerstone of many biological processes and, together, they form various types of molecular machinery that perform a vast array of biological functions. Different complexes perform different functions and, the same complex can perform very different functions that depend on a variety of factors. Thus disruption of protein complexes can be lethal to an organism. It is in...