BACKGROUND In acute myeloid leukemia (AML), disseminated intravascular coagulation (DIC) contributes to morbidity and mortality, but the underlying pathomechanisms remain incompletely understood. METHODS We conducted a prospective study on 69 patients with newly diagnosed AML to further define the correlates of systemic coagulation activation in this hematological malignancy. Tissue factor pr...

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare but severe pulmonary complication of malignant tumors. It characterized by the presence multiple microscopic emboli attached to endothelium small arteries and induces fibrointimal proliferation activation coagulation. The main clinical manifestations PTTM are dyspnea, dry cough, hypoxemia, hypertension, right heart failure, thrombocyto...

Activation of inflammatory and coagulation pathways is an important event in the pathogenesis of sepsis. In sepsis, which can be defined as the disadvantageous systemic host response to infection, the blood coagulation system is triggered. Activation of coagulation and deposition of fibrin as a consequence of inflammation can be considered instrumental in containing inflammatory activity to the...

INTRODUCTION We tested two hypotheses that disseminated intravascular coagulation (DIC) and acute coagulopathy of trauma-shock (ACOTS) in the early phase of trauma are similar disease entities and that the DIC score on admission can be used to predict the prognosis of patients with coagulopathy of trauma. METHODS We conducted a retrospective study of 562 trauma patients, including 338 patient...

conclusions the viral load in patients who suffer from cchf has a direct significant correlation with disease severity. viral load above 8.6 × 105 copies/ml on the first day of admission is a predictor of severe cchf. background crimean-congo hemorrhagic fever (cchf) is an endemic disease in south eastern of iran, especially in sistan and baluchestan province. cchf is a potentially fatal diseas...