PURPOSE The objective of this study was to investigate the clinicopathologic features of carcinoma ex pleomorphic adenoma (CXPA) and comprehensively improve an understanding of this disease. MATERIALS AND METHODS This retrospective study investigated 151 cases of histologically confirmed CXPA. Disease-specific survival, local recurrence, and regional and distant metastases were analyzed. RE...

follicular thyroid carcinoma (ftc) is the second most common type of thyroid cancer after papillary carcinoma. it usually grows slowly and is clinically indolent; but rarely, its aggressive forms with distant metastases can occur. we report here an uncommon case of bilateral orbital metastasis of ftc. a 70-year-old woman presented with bilateral exophtalmus and past medical history of thyroid n...

in research institute for nuclear medicine (tehran university of medical sciences) 50 patients with follicular thyroid carcinoma were evaluted retrospectively. the purpose of the study was assesment of the response of iodine-131 therapy. the best result were achieved when the patient treated with iodine-131 for the first time, in the 4th decade of life, with total thyroidectomy and no metastasi...

introduction : galectin-3, a member of the family of β-galactoside-binding animal lectins, has been implicated in tumor invasion and metastasis. materials and methods : using an elisakit, we assessed the circulating levels of galectin-3 in sera from 40 oral squamous cell carcinoma (oscc) patients and from 43 healthy controls. results : serum galectin-3 levels in oscc patients were significantly...

BACKGROUND It is important to evaluate the curability of and avoid unnecessary exploratory surgery for gastric cancer preoperatively. However, no related research has been reported until now. The aim of this study was to evaluate the factors influencing surgery for incurable gastric cancer. METHODS 310 cases of T3-4 gastric cancer patients were analyzed retrospectively, including 141 cases wi...

BACKGROUND To evaluate whether tumor invasion depth can be a reliable and easily applicable pathologic assessment strategy to predict outcomes using surgically resected cervical squamous cell carcinoma specimens from patients who have received neoadjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CCRT). METHODS We included 173 patients with cervical squamous cell carcinoma who receiv...

BACKGROUND XB130 is a newly discovered adaptor protein for intracellular signal transduction; it is involved in gene regulation, cell proliferation, cell survival, cell migration, and tumorigenesis. However, its expression and role in pancreatic ductal adenocarcinoma (PDAC) have not been investigated. The present study was designed to clarify the prognostic significance of XB130 expression in P...

Purpose: Papillary thyroid microcarcinomas (PTMC), which are not palpable and have no clinical symptoms are 1.0 cm or less in diameter. The optimal extent of thyroid tumor resection has been controversial. We investigated clinicopathological findings of PTMC of 5 mm or less in diameter for reasonable therapeutic approach. Methods: From, Jan. 2002 to Dec. 2006, 366 patients underwent thyroidecto...

We determined whether active PI3K signaling together with nuclear accumulation of β-Catenin is necessary to fully activate canonical WNT signaling and examined the association of both signaling pathways with colon cancer progression. Using reporter gene assays we examined the activation of β-Catenin mediated transcription upon PI3K inhibition with or without β-Catenin nuclear accumulation. Ecto...

OBJECTIVES/HYPOTHESIS Squamous cell carcinoma of the nasal cavity (NCSCC) is an infrequent malignancy that has been historically difficult to characterize. This study provides new insight into NCSCC utilizing a population-based database. We analyze the propensity for cervical and distant metastasis from NCSCC, as well as survival outcomes. STUDY DESIGN Retrospective database analysis. METHO...